Seroatlas · Human Serome Atlas

CERS2

Ceramide synthase 2

Also known as: CERS2_HUMAN, FLJ10243, LASS2, SP260

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96G23
Gene
CERS2
Ensembl
ENSG00000143418
Chromosome
1
Canonical length
380 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Nuclear membrane,Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q96G23|CERS2
     1  MLQTLYDYFW WERLWLPVNL TWADLEDRDG RVYAKASDLY ITLPLALLFL IVRYFFELYV
    61  ATPLAALLNI KEKTRLRAPP NATLEHFYLT SGKQPKQVEV ELLSRQSGLS GRQVERWFRR
   121  RRNQDRPSLL KKFREASWRF TFYLIAFIAG MAVIVDKPWF YDMKKVWEGY PIQSTIPSQY
   181  WYYMIELSFY WSLLFSIASD VKRKDFKEQI IHHVATIILI SFSWFANYIR AGTLIMALHD
   241  SSDYLLESAK MFNYAGWKNT CNNIFIVFAI VFIITRLVIL PFWILHCTLV YPLELYPAFF
   301  GYYFFNSMMG VLQLLHIFWA YLILRMAHKF ITGKLVEDER SDREETESSE GEEAAAGGGA
   361  KSRPLANGHP ILNNNHRKND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CERS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
684 nTPM

Expression across tissuesHPA

Tissue

  • liver: 684 nTPM
  • spinal cord: 290 nTPM
  • adrenal gland: 259 nTPM
  • kidney: 244 nTPM
  • thyroid gland: 151 nTPM
  • choroid plexus: 150 nTPM

Single-cell type

  • platelets: 400 nCPM
  • hepatocytes: 220 nCPM
  • parietal cells: 154 nCPM
  • alveolar cells type 1: 151 nCPM
  • cholangiocytes: 125 nCPM
  • alveolar cells type 2: 115 nCPM

Immune cell

  • basophil: 213 nTPM
  • eosinophil: 136 nTPM
  • MAIT T-cell: 94 nTPM
  • total PBMC: 89 nTPM
  • neutrophil: 87 nTPM
  • T-reg: 87 nTPM

Brain region

  • white matter: 295 nTPM
  • medulla oblongata: 263 nTPM
  • cerebellum: 196 nTPM
  • basal ganglia: 194 nTPM
  • midbrain: 192 nTPM
  • thalamus: 175 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.48
gnomAD missense Z
1.76
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CERS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CERS2 as an antibody target. Whether an autoantibody or antibody against CERS2 could matter depends on whether native CERS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CERS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CERS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CERS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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