Seroatlas · Human Serome Atlas

CREBL2

cAMP-responsive element-binding protein-like 2

Also known as: CRBL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60519
Gene
CREBL2
Ensembl
ENSG00000111269
Chromosome
12
Canonical length
120 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>O60519|CREBL2
     1  MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSRER
    61  AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS QQNSSRHTKA GKTDANSNSW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREBL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 123 nTPM
  • parathyroid gland: 53 nTPM
  • liver: 47 nTPM
  • kidney: 46 nTPM
  • thyroid gland: 42 nTPM
  • adipose tissue: 37 nTPM

Single-cell type

  • kupffer cells: 243 nCPM
  • adrenal cortex cells: 169 nCPM
  • microglia: 121 nCPM
  • retinal pigment epithelial cells: 98 nCPM
  • macrophages: 92 nCPM
  • parietal cells: 81 nCPM

Immune cell

  • intermediate monocyte: 5.6 nTPM
  • T-reg: 5.6 nTPM
  • memory CD4 T-cell: 3.4 nTPM
  • naive CD4 T-cell: 3.3 nTPM
  • MAIT T-cell: 3.1 nTPM
  • myeloid DC: 2.8 nTPM

Brain region

  • choroid plexus: 42 nTPM
  • hypothalamus: 41 nTPM
  • white matter: 38 nTPM
  • cerebral cortex: 37 nTPM
  • basal ganglia: 35 nTPM
  • spinal cord: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.72
gnomAD missense Z
1.5
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CREBL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREBL2 as an antibody target. Whether an autoantibody or antibody against CREBL2 could matter depends on whether native CREBL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREBL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREBL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CREBL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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