Seroatlas · Human Serome Atlas

CREBZF

CREB/ATF bZIP transcription factor

Also known as: ZF, ZHANG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS37
Gene: CREBZF
Ensembl: ENSG00000137504
Chromosome: 11
Canonical length: 354 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Located in mitochondrion and nucleoplasm. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q9NS37|CREBZF
     1  MRHSLTKLLA ASGSNSPTRS ESPEPAATCS LPSDLTRAAA GEEETAAAGS PGRKQQFGDE
    61  GELEAGRGSR GGVAVRAPSP EEMEEEAIAS LPGEETEDMD FLSGLELADL LDPRQPDWHL
   121  DPGLSSPGPL SSSGGGSDSG GLWRGDDDDE AAAAEMQRFS DLLQRLLNGI GGCSSSSDSG
   181  SAEKRRRKSP GGGGGGGSGN DNNQAATKSP RKAAAAAARL NRLKKKEYVM GLESRVRGLA
   241  AENQELRAEN RELGKRVQAL QEESRYLRAV LANETGLARL LSRLSGVGLR LTTSLFRDSP
   301  AGDHDYALPV GKQKQDLLEE DDSAGGVCLH VDKDKVSVEF CSACARKASS SLKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREBZF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

ovary: 26 nTPM
cerebellum: 23 nTPM
retina: 23 nTPM
endometrium: 20 nTPM
cervix: 19 nTPM
pancreas: 18 nTPM

Single-cell type

bergmann glia: 129 nCPM
lactotrophs: 109 nCPM
myonuclei: 109 nCPM
oligodendrocytes: 106 nCPM
fibro-adipogenic progenitors: 101 nCPM
somatotrophs: 97 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
basophil: 0.3 nTPM
gdT-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebellum: 26 nTPM
white matter: 19 nTPM
choroid plexus: 15 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 14 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.1
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CREBZF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREBZF as an antibody target. Whether an autoantibody or antibody against CREBZF could matter depends on whether native CREBZF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREBZF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREBZF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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