Seroatlas · Human Serome Atlas

CFAP299

Cilia- and flagella-associated protein 299

Also known as: C4orf22, CF299_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6V702
Gene: CFAP299
Ensembl: ENSG00000197826
Chromosome: 4
Canonical length: 233 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q6V702|CFAP299
     1  MDQEEGLKAL DNIVTQFNAY EDFLDSQITT VDLYYLEDET LARQLVELGY RGTGERVKRE
    61  DFEARKAAIE IARLAERAQQ KTLTSAGKDL QDNFLTALAM REEDNRSGKL SSVIFIRDRN
   121  SHGQEISGYI DYAHRLKTED FEVYFTGKKR LLPRPTDISF YNWDADIAVS NSSPNYQVIA
   181  DNPEGLLFRY KRDRKILNVD PKAQPGDNST RITILTELYV QAVIFDHISR RKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP299 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
fallopian tube: 19 nTPM
choroid plexus: 5 nTPM
hippocampal formation: 3.2 nTPM
hypothalamus: 3 nTPM
basal ganglia: 2.3 nTPM

Single-cell type

ependymal cells: 5,123 nCPM
respiratory ciliated cells: 3,062 nCPM
fallopian tube ciliated cells: 1,252 nCPM
endometrial ciliated cells: 1,251 nCPM
epididymal efferent duct ciliated cells: 1,020 nCPM
respiratory deuterosomal cells: 401 nCPM

Immune cell

naive B-cell: 0.6 nTPM
memory B-cell: 0.2 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

medulla oblongata: 12 nTPM
midbrain: 8 nTPM
spinal cord: 7.9 nTPM
choroid plexus: 6 nTPM
pons: 4.6 nTPM
cerebellum: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4464
Domain of unknown function (DUF4464)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP299 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NFE2L2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP299 as an antibody target. Whether an autoantibody or antibody against CFAP299 could matter depends on whether native CFAP299 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP299 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP299 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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