MAP2K6

Protein identityUniProt · HPA

UniProt accession

P52564

Gene

MAP2K6

Ensembl

ENSG00000108984

Chromosome

17

Canonical length

334 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>P52564|MAP2K6
     1  MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG
    61  RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF
   121  REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV
   181  KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI
   241  WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK
   301  ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP2K6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

41 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for MAP2K6 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.91

gnomAD missense Z

3.01

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• bone development
• cardiac muscle contraction
• cellular senescence
• MAPK cascade
• negative regulation of cold-induced thermogenesis
• nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
• osteoblast differentiation
• p38MAPK cascade
• positive regulation of MAPK cascade
• regulation of cell cycle
• regulation of signal transduction by p53 class mediator
• signal transduction
• signal transduction in response to DNA damage
• stress-activated MAPK cascade
• stress-activated protein kinase signaling cascade

Molecular functions

• ATP binding
• identical protein binding
• MAP kinase kinase activity
• protein kinase binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• protein tyrosine kinase activity

Cellular components

• cytoplasm
• cytoskeleton
• cytosol
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Protein kinase domain

KeywordsUniProt

• Acetylation
• Apoptosis
• ATP-binding
• Cytoplasm
• Cytoskeleton
• Kinase
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Serine/threonine-protein kinase
• Stress response
• Transcription
• Transcription regulation
• Transferase
• Tyrosine-protein kinase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MAP2K6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DCTN1
• EIF2AK2
• TAOK2
• MAP3K4
• LRRK2
• MAPK14
• NFE2L2