MRPL53

Protein identityUniProt · HPA

UniProt accession

Q96EL3

Gene

MRPL53

Ensembl

ENSG00000204822

Chromosome

2

Canonical length

112 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q96EL3|MRPL53
     1  MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS VIADVRHDGS
    61  EPCVDVLFGD GHRLIMRGAH LTALEMLTAF ASHIRARDAA GSGDKPGADT GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

205 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0.28

gnomAD missense Z

-0.64

DepMap mean gene effect

-0.57

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation

Cellular components

• mitochondrial inner membrane
• mitochondrial large ribosomal subunit
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein mL53
• Mitochondrial Large Ribosomal Subunit mL53
• 39S ribosomal protein L53/MRP-L53

KeywordsUniProt

• Mitochondrion
• Ribonucleoprotein
• Ribosomal protein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of MRPL53 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HNRNPH1
• MRPL1
• MRPL10
• MRPL12
• MRPL50
• MRPL58
• MRPL9
• MRPS18A
• MTIF2