Seroatlas · Human Serome Atlas

COPRS

Coordinator of PRMT5 and differentiation stimulator

Also known as: C17orf79, COPR5, COPRS_HUMAN, HSA272196, TTP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQ92
Gene: COPRS
Ensembl: ENSG00000172301
Chromosome: 17
Canonical length: 184 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables histone binding activity. Involved in chromatin remodeling. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q9NQ92|COPRS
     1  MDLQAAGAQA QGAAEPSRGP PLPSARGAPP SPEAGFATAD HSSQERETEK AMDRLARGTQ
    61  SIPNDSPARG EGTHSEEEGF AMDEEDSDGE LNTWELSEGT NCPPKEQPGD LFNEDWDSEL
   121  KADQGNPYDA DDIQESISQE LKPWVCCAPQ GDMIYDPSWH HPPPLIPYYS KMVFETGQFD
   181  DAED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPRS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 244 nTPM

Expression across tissuesHPA

Tissue

testis: 244 nTPM
choroid plexus: 174 nTPM
cerebral cortex: 146 nTPM
hypothalamus: 137 nTPM
amygdala: 125 nTPM
basal ganglia: 121 nTPM

Single-cell type

late primary spermatocytes: 982 nCPM
late spermatids: 422 nCPM
epididymal efferent duct ciliated cells: 331 nCPM
fallopian tube ciliated cells: 289 nCPM
epididymal principal cells: 252 nCPM
epididymal clear cells: 231 nCPM

Immune cell

naive B-cell: 3.6 nTPM
myeloid DC: 2.6 nTPM
classical monocyte: 2 nTPM
intermediate monocyte: 2 nTPM
memory B-cell: 1.9 nTPM
basophil: 1.8 nTPM

Brain region

hypothalamus: 81 nTPM
choroid plexus: 66 nTPM
basal ganglia: 66 nTPM
thalamus: 65 nTPM
pons: 65 nTPM
cerebral cortex: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.25
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

histone binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coordinator of PRMT5 and differentiation stimulator
Cooperator of PRMT5 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPRS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPRS as an antibody target. Whether an autoantibody or antibody against COPRS could matter depends on whether native COPRS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPRS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPRS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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