Epithelial Splicing Regulatory
IPR050666
Definition
The ESRP family is involved in the regulation of mRNA splicing, playing a crucial role in the formation of cell type-specific isoforms, particularly in epithelial cells. Family members are known to regulate the expression of FGFR2-IIIb, an epithelial-specific isoform of FGFR2, and are implicated in the splicing of various transcripts during the epithelial-to-mesenchymal transition (EMT). They act by directly binding to specific sequences in mRNAs, such as GU-rich motifs in regulatory regions. Some family members also participate in the regulation of alternative splicing in embryo development and are involved in processes like inner ear development and auditory hair cell differentiation. Additionally, hnRNP proteins within this family contribute to pre-mRNA processing events, forming complexes that are essential for the conversion of pre-mRNAs into functional, translatable mRNAs in the cytoplasm.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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