Seroatlas · Human Serome Atlas

NUDT16L1

Tudor-interacting repair regulator protein

Also known as: SDOS, TIRR, TIRR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRJ7
Gene: NUDT16L1
Ensembl: ENSG00000168101
Chromosome: 16
Canonical length: 211 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables snoRNA binding activity. Involved in negative regulation of double-strand break repair via nonhomologous end joining. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q9BRJ7|NUDT16L1
     1  MSTAAVPELK QISRVEAMRL GPGWSHSCHA MLYAANPGQL FGRIPMRFSV LMQMRFDGLL
    61  GFPGGFVDRR FWSLEDGLNR VLGLGLGCLR LTEADYLSSH LTEGPHRVVA HLYARQLTLE
   121  QLHAVEISAV HSRDHGLEVL GLVRVPLYTQ KDRVGGFPNF LSNAFVSTAK CQLLFALKVL
   181  NMMPEEKLVE ALAAATEKQK KALEKLLPAS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT16L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

liver: 63 nTPM
heart muscle: 56 nTPM
kidney: 50 nTPM
cerebellum: 49 nTPM
basal ganglia: 45 nTPM
adrenal gland: 45 nTPM

Single-cell type

esophageal apical cells: 122 nCPM
esophageal suprabasal cells: 88 nCPM
epididymal principal cells: 71 nCPM
enterocytes: 68 nCPM
cytotrophoblasts: 65 nCPM
esophageal basal cells: 63 nCPM

Immune cell

total PBMC: 94 nTPM
eosinophil: 92 nTPM
plasmacytoid DC: 80 nTPM
T-reg: 75 nTPM
naive CD4 T-cell: 71 nTPM
neutrophil: 65 nTPM

Brain region

medulla oblongata: 42 nTPM
choroid plexus: 41 nTPM
basal ganglia: 39 nTPM
white matter: 38 nTPM
thalamus: 37 nTPM
hippocampal formation: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of double-strand break repair via nonhomologous end joining

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDT16L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT16L1 as an antibody target. Whether an autoantibody or antibody against NUDT16L1 could matter depends on whether native NUDT16L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT16L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT16L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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