Seroatlas · Human Serome Atlas

SNRPC

U1 small nuclear ribonucleoprotein C

Also known as: RU1C_HUMAN, U1-C, Yhc1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09234
Gene
SNRPC
Ensembl
ENSG00000124562
Chromosome
6
Canonical length
159 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>P09234|SNRPC
     1  MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI DKTTAAFQQG
    61  KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP PMMPMMGPPP PGMMPVGPAP
   121  GMRPPMGGHM PMMPGPPMMR PPARPMMVPT RPGMTRPDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
194 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 194 nTPM
  • bone marrow: 167 nTPM
  • skeletal muscle: 164 nTPM
  • testis: 125 nTPM
  • tongue: 117 nTPM
  • thymus: 108 nTPM

Single-cell type

  • late primary spermatocytes: 737 nCPM
  • hofbauer cells: 331 nCPM
  • oocytes: 304 nCPM
  • cytotrophoblasts: 281 nCPM
  • migrating cytotrophoblasts: 278 nCPM
  • extravillous trophoblasts: 250 nCPM

Immune cell

  • total PBMC: 246 nTPM
  • non-classical monocyte: 240 nTPM
  • T-reg: 236 nTPM
  • memory B-cell: 235 nTPM
  • naive B-cell: 212 nTPM
  • plasmacytoid DC: 208 nTPM

Brain region

  • white matter: 64 nTPM
  • spinal cord: 58 nTPM
  • choroid plexus: 57 nTPM
  • basal ganglia: 53 nTPM
  • thalamus: 53 nTPM
  • cerebellum: 53 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRPC.

Disease | ImmuneIEDB

Conditions an epitope on SNRPC was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against SNRPC are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for SNRPC from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

3 publications

Reference: B cellIEDB

10 publications

Show 5 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.72
gnomAD missense Z
2.55
DepMap mean gene effect
-0.79
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPC as an antibody target. Whether an autoantibody or antibody against SNRPC could matter depends on whether native SNRPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases.

Canonical record: https://seroatlas.com/gene/SNRPC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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