RRM HNRPC family, RALY subfamily
IPR051186
Definition
The RRM HNRPC family, RALY subfamily, comprises RNA-binding proteins involved in various aspects of RNA metabolism. Members of this family bind to pre-mRNA and are implicated in the assembly of hnRNP particles, playing a role in mRNA stability, translation, and splicing. They interact with poly-U tracts in mRNA UTRs and respond to m6A modifications, which can influence mRNA splicing. Some family members are involved in transcriptional regulation of cholesterol biosynthesis by binding non-coding RNAs like LeXis. Others may contribute to nucleosome assembly and maintenance of mRNA levels. The family is characterized by the RNA recognition motif (RRM) and is associated with heterogeneous nuclear ribonucleoproteins (hnRNPs), which are key components in the post-transcriptional regulation of gene expression.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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