Seroatlas · Human Serome Atlas

FYTTD1

UAP56-interacting factor

Also known as: DKFZp761B1514, UIF, UIF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QD9
Gene: FYTTD1
Ensembl: ENSG00000122068
Chromosome: 3
Canonical length: 318 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables mRNA binding activity. Involved in mRNA export from nucleus. Located in cytosol; nuclear speck; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q96QD9|FYTTD1
     1  MNRFGTRLVG ATATSSPPPK ARSNENLDKI DMSLDDIIKL NRKEGKKQNF PRLNRRLLQQ
    61  SGAQQFRMRV RWGIQQNSGF GKTSLNRRGR VMPGKRRPNG VITGLAARKT TGIRKGISPM
   121  NRPPLSDKNI EQYFPVLKRK ANLLRQNEGQ RKPVAVLKRP SQLSRKNNIP ANFTRSGNKL
   181  NHQKDTRQAT FLFRRGLKVQ AQLNTEQLLD DVVAKRTRQW RTSTTNGGIL TVSIDNPGAV
   241  QCPVTQKPRL TRTAVPSFLT KREQSDVKKV PKGVPLQFDI NSVGKQTGMT LNERFGILKE
   301  QRATLTYNKG GSRFVTVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FYTTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 87 nTPM
tongue: 63 nTPM
esophagus: 41 nTPM
heart muscle: 39 nTPM
testis: 38 nTPM
bone marrow: 37 nTPM

Single-cell type

pdcs: 247 nCPM
esophageal apical cells: 244 nCPM
cardiomyocytes: 214 nCPM
ocular epithelial cells: 160 nCPM
suprabasal keratinocytes: 111 nCPM
esophageal suprabasal cells: 107 nCPM

Immune cell

NK-cell: 65 nTPM
basophil: 59 nTPM
total PBMC: 46 nTPM
MAIT T-cell: 41 nTPM
memory CD8 T-cell: 36 nTPM
naive CD4 T-cell: 34 nTPM

Brain region

cerebellum: 41 nTPM
hypothalamus: 39 nTPM
cerebral cortex: 38 nTPM
white matter: 38 nTPM
midbrain: 37 nTPM
pons: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.4
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA export from nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

UAP56-interacting factor
Forty-two-three protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FYTTD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FYTTD1 as an antibody target. Whether an autoantibody or antibody against FYTTD1 could matter depends on whether native FYTTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FYTTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FYTTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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