Seroatlas · Human Serome Atlas

KMT5A

N-lysine methyltransferase KMT5A

Also known as: KMT5A_HUMAN, PR-Set7, SET07, SET8, SETD8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQR1
Gene
KMT5A
Ensembl
ENSG00000183955
Chromosome
12
Canonical length
393 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q9NQR1|KMT5A
     1  MGEGGAAAAL VAAAAAAAAA AAAVVAGQRR RRLGRRARCH GPGRAAGGKM SKPCAVEAAA
    61  AAVAATAPGP EMVERRGPGR PRTDGENVFT GQSKIYSYMS PNKCSGMRFP LQEENSVTHH
   121  EVKCQGKPLA GIYRKREEKR NAGNAVRSAM KSEEQKIKDA RKGPLVPFPN QKSEAAEPPK
   181  TPPSSCDSTN AAIAKQALKK PIKGKQAPRK KAQGKTQQNR KLTDFYPVRR SSRKSKAELQ
   241  SEERKRIDEL IESGKEEGMK IDLIDGKGRG VIATKQFSRG DFVVEYHGDL IEITDAKKRE
   301  ALYAQDPSTG CYMYYFQYLS KTYCVDATRE TNRLGRLINH SKCGNCQTKL HDIDGVPHLI
   361  LIASRDIAAG EELLYDYGDR SKASIEAHPW LKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KMT5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 48 nTPM
  • bone marrow: 37 nTPM
  • blood vessel: 35 nTPM
  • prostate: 35 nTPM
  • skin: 33 nTPM
  • vagina: 30 nTPM

Single-cell type

  • erythrocyte progenitors: 136 nCPM
  • smooth muscle cells: 91 nCPM
  • esophageal apical cells: 86 nCPM
  • suprabasal keratinocytes: 81 nCPM
  • ocular epithelial cells: 71 nCPM
  • basal keratinocytes: 56 nCPM

Immune cell

  • eosinophil: 4.3 nTPM
  • MAIT T-cell: 2.7 nTPM
  • basophil: 2.3 nTPM
  • NK-cell: 2.3 nTPM
  • intermediate monocyte: 2.1 nTPM
  • memory CD8 T-cell: 2.1 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • white matter: 26 nTPM
  • thalamus: 24 nTPM
  • pons: 24 nTPM
  • midbrain: 23 nTPM
  • amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
DepMap mean gene effect
-0.69
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KMT5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KMT5A as an antibody target. Whether an autoantibody or antibody against KMT5A could matter depends on whether native KMT5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KMT5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KMT5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KMT5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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