Heterogeneous nuclear ribonucleoprotein C

Definition

This entry represents heterogeneous nuclear ribonucleoproteins C and C-like. The physiologically active form of human heterogeneous nuclear ribonucleoprotein C (hnRNPC) is a tetramer of isoforms hnRNPC1 and C2. It binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single hnRNPC tetramers bind 230-240 nucleotides. It may play a role in the early steps of spliceosome assembly and pre-mRNA splicing. It interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules [[cite:PMID:8264621], [cite:PMID:7567451], [cite:PMID:12509468], [cite:PMID:16010978]]. Among the hnRNP C-like proteins is Raly, a protein described in mouse and humans PMID:10500250.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• HNRNPC
• HNRNPCL1
• HNRNPCL2
• HNRNPCL3
• HNRNPCL4
• RALY
• RALYL