Seroatlas · Human Serome Atlas

RNF4

E3 ubiquitin-protein ligase RNF4

Also known as: RES4-26, RNF4_HUMAN, SLX5, SNURF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78317
Gene
RNF4
Ensembl
ENSG00000063978
Chromosome
4
Canonical length
190 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Microtubule ends
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>P78317|RNF4
     1  MSTRKRRGGA INSRQAQKRT REATSTPEIS LEAEPIELVE TAGDEIVDLT CESLEPVVVD
    61  LTHNDSVVIV DERRRPRRNA RRLPQDHADS CVVSSDDEEL SRDRDVYVTT HTPRNARDEG
   121  ATGLRPSGTV SCPICMDGYS EIVQNGRLIV STECGHVFCS QCLRDSLKNA NTCPTCRKKI
   181  NHKRYHPIYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 47 nTPM
  • thymus: 47 nTPM
  • lymph node: 47 nTPM
  • bone marrow: 44 nTPM
  • spleen: 40 nTPM
  • appendix: 34 nTPM

Single-cell type

  • ependymal cells: 80 nCPM
  • proximal tubule cells: 76 nCPM
  • choroid plexus epithelial cells: 59 nCPM
  • neutrophil progenitors: 56 nCPM
  • cone photoreceptor cells: 54 nCPM
  • renal connecting tubule cells: 53 nCPM

Immune cell

  • total PBMC: 129 nTPM
  • eosinophil: 105 nTPM
  • non-classical monocyte: 104 nTPM
  • NK-cell: 100 nTPM
  • T-reg: 99 nTPM
  • gdT-cell: 98 nTPM

Brain region

  • thalamus: 53 nTPM
  • choroid plexus: 52 nTPM
  • midbrain: 52 nTPM
  • cerebral cortex: 52 nTPM
  • medulla oblongata: 52 nTPM
  • cerebellum: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.8
gnomAD missense Z
1.07
DepMap mean gene effect
-0.54
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF4 as an antibody target. Whether an autoantibody or antibody against RNF4 could matter depends on whether native RNF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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