Seroatlas · Human Serome Atlas

KHDRBS1

KH domain-containing, RNA-binding, signal transduction-associated protein 1

Also known as: FLJ34027, KHDR1_HUMAN, p62, Sam68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07666
Gene
KHDRBS1
Ensembl
ENSG00000121774
Chromosome
1
Canonical length
443 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q07666|KHDRBS1
     1  MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG SRGGARASPA
    61  TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE NKYLPELMAE KDSLDPSFTH
   121  AMQLLTAEIE KIQKGDSKKD DEENYLDLFS HKNMKLKERV LIPVKQYPKF NFVGKILGPQ
   181  GNTIKRLQEE TGAKISVLGK GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA
   241  YALMAHAMEE VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVPVRG RGAAPPPPPV
   301  PRGRGVGPPR GALVRGTPVR GAITRGATVT RGVPPPPTVR GAPAPRARTA GIQRIPLPPP
   361  PAPETYEEYG YDDTYAEQSY EGYEGYYSQS QGDSEYYDYG HGEVQDSYEA YGQDDWNGTR
   421  PSLKAPPARP VKGAYREHPY GRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KHDRBS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 106 nTPM
  • thymus: 105 nTPM
  • tonsil: 91 nTPM
  • bone marrow: 88 nTPM
  • lymph node: 88 nTPM
  • endometrium: 77 nTPM

Single-cell type

  • extravillous trophoblasts: 315 nCPM
  • neutrophils: 299 nCPM
  • esophageal basal cells: 297 nCPM
  • migrating cytotrophoblasts: 291 nCPM
  • cytotrophoblasts: 271 nCPM
  • monocyte progenitors: 252 nCPM

Immune cell

  • MAIT T-cell: 12 nTPM
  • memory B-cell: 10 nTPM
  • naive CD4 T-cell: 9.8 nTPM
  • naive CD8 T-cell: 9.5 nTPM
  • T-reg: 9.3 nTPM
  • memory CD4 T-cell: 9.2 nTPM

Brain region

  • white matter: 79 nTPM
  • cerebellum: 77 nTPM
  • spinal cord: 77 nTPM
  • medulla oblongata: 70 nTPM
  • hypothalamus: 67 nTPM
  • midbrain: 66 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KHDRBS1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.99
gnomAD missense Z
2.42
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KHDRBS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KHDRBS1 as an antibody target. Whether an autoantibody or antibody against KHDRBS1 could matter depends on whether native KHDRBS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KHDRBS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KHDRBS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KHDRBS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...