PPIA
Peptidyl-prolyl cis-trans isomerase A
Also known as: CYPA, PPIA_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P62937
- Gene
- PPIA
- Ensembl
- ENSG00000196262
- Chromosome
- 7
- Canonical length
- 165 aa
- Protein class
- Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>P62937|PPIA
1 MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF
61 MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE
121 WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLELocalizationUniProt · AlphaFold · HPA
Whether an antibody against PPIA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 2,172 nTPM
Expression across tissuesHPA
Tissue
- thymus: 2,172 nTPM
- esophagus: 2,171 nTPM
- choroid plexus: 1,973 nTPM
- cerebral cortex: 1,784 nTPM
- amygdala: 1,670 nTPM
- spinal cord: 1,560 nTPM
Single-cell type
- gastric progenitor cells: 3,095 nCPM
- megakaryocytes: 1,360 nCPM
- enteric transient amplifying cells: 1,306 nCPM
- extravillous trophoblasts: 1,265 nCPM
- hofbauer cells: 1,183 nCPM
- enteric stem cells: 1,083 nCPM
Immune cell
- total PBMC: 3,646 nTPM
- plasmacytoid DC: 2,631 nTPM
- myeloid DC: 2,205 nTPM
- memory B-cell: 2,116 nTPM
- T-reg: 2,094 nTPM
- naive B-cell: 1,782 nTPM
Brain region
- pons: 983 nTPM
- cerebral cortex: 954 nTPM
- white matter: 910 nTPM
- medulla oblongata: 873 nTPM
- hypothalamus: 847 nTPM
- spinal cord: 789 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about PPIA.
Disease | ImmuneIEDB
Conditions an epitope on PPIA was assayed in.
- rheumatoid arthritis B cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.71
- gnomAD pLI
- 0.56
- gnomAD missense Z
- 1.99
- DepMap mean gene effect
- -0.84
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- activation of protein kinase B activity
- apoptotic process
- cell adhesion molecule production
- cellular response to oxidative stress
- endothelial cell activation
- leukocyte chemotaxis
- lipid droplet organization
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- negative regulation of protein K48-linked ubiquitination
- negative regulation of protein kinase activity
- negative regulation of protein phosphorylation
- negative regulation of stress-activated MAPK cascade
- negative regulation of viral life cycle
- neuron differentiation
- neutrophil chemotaxis
- platelet activation
- platelet aggregation
- positive regulation of MAPK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of protein phosphorylation
- positive regulation of protein secretion
- positive regulation of viral genome replication
- protein folding
- protein peptidyl-prolyl isomerization
- regulation of apoptotic signaling pathway
- regulation of viral genome replication
- viral release from host cell
Molecular functions
- cyclosporin A binding
- heparan sulfate binding
- integrin binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- unfolded protein binding
- virion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PPIA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PPIA as an antibody target. Whether an autoantibody or antibody against PPIA could matter depends on whether native PPIA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PPIA is annotated at the cell surface, where native PPIA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PPIA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...