GNG10
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Also known as: GBG10_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P50151
- Gene
- GNG10
- Ensembl
- ENSG00000242616
- Chromosome
- 9
- Canonical length
- 68 aa
- Protein class
- Predicted intracellular proteins, RAS pathway related proteins
OverviewNCBI Gene
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
68 residues, UniProt reviewed canonical sequence.
>P50151|GNG10
1 MSSGASASAL QRLVEQLKLE AGVERIKVSQ AAAELQQYCM QNACKDALLV GVPAGSNPFR
61 EPRSCALLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GNG10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- urinary bladder: 115 nTPM
- parathyroid gland: 93 nTPM
- adipose tissue: 92 nTPM
- appendix: 88 nTPM
- adrenal gland: 88 nTPM
- amygdala: 83 nTPM
Single-cell type
- microglia: 26 nCPM
- other brain neurons: 21 nCPM
- oligodendrocytes: 20 nCPM
- brain excitatory neurons: 18 nCPM
- oligodendrocyte progenitor cells: 18 nCPM
- brain inhibitory neurons: 14 nCPM
Immune cell
- neutrophil: 515 nTPM
- eosinophil: 84 nTPM
- classical monocyte: 58 nTPM
- intermediate monocyte: 55 nTPM
- myeloid DC: 50 nTPM
- non-classical monocyte: 47 nTPM
Brain region
- hypothalamus: 44 nTPM
- midbrain: 36 nTPM
- white matter: 36 nTPM
- medulla oblongata: 35 nTPM
- cerebral cortex: 33 nTPM
- hippocampal formation: 31 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.96
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GNG10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GNG10 as an antibody target. Whether an autoantibody or antibody against GNG10 could matter depends on whether native GNG10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GNG10 is annotated at the cell surface, where native GNG10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GNG10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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