Seroatlas · Human Serome Atlas

VBP1

Prefoldin subunit 3

Also known as: PFD3, PFD3_HUMAN, PFDN3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61758
Gene: VBP1
Ensembl: ENSG00000155959
Chromosome: X
Canonical length: 197 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>P61758|VBP1
     1  MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL KKLDEQYQKY
    61  KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS METRFLLADN LYCKASVPPT
   121  DKVCLWLGAN VMLEYDIDEA QALLEKNLST ATKNLDSLEE DLDFLRDQFT TTEVNMARVY
   181  NWDVKRRNKD DSTKNKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

tongue: 113 nTPM
skeletal muscle: 95 nTPM
spinal cord: 80 nTPM
midbrain: 66 nTPM
heart muscle: 62 nTPM
hypothalamus: 59 nTPM

Single-cell type

megakaryocytes: 223 nCPM
erythrocyte progenitors: 132 nCPM
extravillous trophoblasts: 120 nCPM
esophageal apical cells: 119 nCPM
early primary spermatocytes: 113 nCPM
esophageal suprabasal cells: 113 nCPM

Immune cell

eosinophil: 76 nTPM
T-reg: 43 nTPM
naive CD8 T-cell: 38 nTPM
myeloid DC: 36 nTPM
naive CD4 T-cell: 35 nTPM
total PBMC: 33 nTPM

Brain region

white matter: 56 nTPM
spinal cord: 46 nTPM
cerebellum: 46 nTPM
hypothalamus: 44 nTPM
pons: 43 nTPM
medulla oblongata: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.88
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.59
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VBP1 as an antibody target. Whether an autoantibody or antibody against VBP1 could matter depends on whether native VBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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