Seroatlas · Human Serome Atlas

PDRG1

p53 and DNA damage-regulated protein 1

Also known as: C20orf126, dJ310O13.3, PDRG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUG6
Gene: PDRG1
Ensembl: ENSG00000088356
Chromosome: 20
Canonical length: 133 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments

OverviewNCBI Gene

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein stabilization. Part of RPAP3/R2TP/prefoldin-like complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>Q9NUG6|PDRG1
     1  MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD LSLSEDVMVC
    61  FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN RLFEAQGKPE LKGFNLNPLN
   121  QDELKALKVI LKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 52 nTPM
testis: 37 nTPM
cerebellum: 25 nTPM
choroid plexus: 17 nTPM
spinal cord: 17 nTPM
bone marrow: 16 nTPM

Single-cell type

late primary spermatocytes: 93 nCPM
oocytes: 78 nCPM
early primary spermatocytes: 65 nCPM
cytotrophoblasts: 56 nCPM
granulosa cells: 54 nCPM
esophageal suprabasal cells: 49 nCPM

Immune cell

naive B-cell: 36 nTPM
memory B-cell: 36 nTPM
plasmacytoid DC: 30 nTPM
NK-cell: 29 nTPM
naive CD4 T-cell: 27 nTPM
naive CD8 T-cell: 24 nTPM

Brain region

cerebellum: 15 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
white matter: 14 nTPM
choroid plexus: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -1.5
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

unfolded protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Prefoldin beta-like
Prefoldin subunit
p53 and DNA damage-regulated protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDRG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDRG1 as an antibody target. Whether an autoantibody or antibody against PDRG1 could matter depends on whether native PDRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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