Seroatlas · Human Serome Atlas

GNG5

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Also known as: GBG5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63218
Gene: GNG5
Ensembl: ENSG00000174021
Chromosome: 1
Canonical length: 68 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>P63218|GNG5
     1  MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR
    61  PQKVCSFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 254 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 254 nTPM
skeletal muscle: 249 nTPM
bone marrow: 168 nTPM
kidney: 159 nTPM
tongue: 152 nTPM
liver: 148 nTPM

Single-cell type

parietal cells: 385 nCPM
colonocytes: 334 nCPM
enterocytes: 314 nCPM
early spermatids: 275 nCPM
enteric transient amplifying cells: 257 nCPM
late primary spermatocytes: 244 nCPM

Immune cell

neutrophil: 880 nTPM
non-classical monocyte: 657 nTPM
intermediate monocyte: 567 nTPM
basophil: 512 nTPM
plasmacytoid DC: 461 nTPM
classical monocyte: 447 nTPM

Brain region

pons: 37 nTPM
medulla oblongata: 36 nTPM
choroid plexus: 35 nTPM
hypothalamus: 35 nTPM
basal ganglia: 32 nTPM
white matter: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0.19
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG5 as an antibody target. Whether an autoantibody or antibody against GNG5 could matter depends on whether native GNG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG5 is annotated at the cell surface, where native GNG5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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