Seroatlas · Human Serome Atlas

PFDN1

Prefoldin subunit 1

Also known as: PFD1, PFD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60925
Gene: PFDN1
Ensembl: ENSG00000113068
Chromosome: 5
Canonical length: 122 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>O60925|PFDN1
     1  MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE IMTLVDETNM
    61  YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY LERSVKEAED NIREMLMARR
   121  AQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PFDN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 140 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 140 nTPM
cerebral cortex: 89 nTPM
heart muscle: 87 nTPM
tongue: 81 nTPM
spinal cord: 78 nTPM
amygdala: 76 nTPM

Single-cell type

epicardial cells: 6,008 nCPM
myonuclei: 192 nCPM
oocytes: 184 nCPM
esophageal apical cells: 165 nCPM
cytotrophoblasts: 142 nCPM
esophageal suprabasal cells: 138 nCPM

Immune cell

basophil: 150 nTPM
intermediate monocyte: 131 nTPM
non-classical monocyte: 131 nTPM
eosinophil: 131 nTPM
T-reg: 130 nTPM
total PBMC: 115 nTPM

Brain region

medulla oblongata: 65 nTPM
cerebellum: 63 nTPM
white matter: 61 nTPM
pons: 59 nTPM
cerebral cortex: 58 nTPM
hypothalamus: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.85
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.62
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PFDN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PFDN1 as an antibody target. Whether an autoantibody or antibody against PFDN1 could matter depends on whether native PFDN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PFDN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PFDN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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