Seroatlas · Human Serome Atlas

PFDN2

Prefoldin subunit 2

Also known as: PFD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHV9
Gene: PFDN2
Ensembl: ENSG00000143256
Chromosome: 1
Canonical length: 154 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q9UHV9|PFDN2
     1  MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME LNEHSLVIDT
    61  LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI IETLTQQLQA KGKELNEFRE
   121  KHNIRLMGED EKPAAKENSE GAGAKASSAG VLVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PFDN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 227 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 227 nTPM
midbrain: 218 nTPM
hypothalamus: 207 nTPM
skeletal muscle: 205 nTPM
amygdala: 185 nTPM
cerebral cortex: 180 nTPM

Single-cell type

oocytes: 1,345 nCPM
basal keratinocytes: 495 nCPM
suprabasal keratinocytes: 474 nCPM
gastric progenitor cells: 400 nCPM
esophageal basal cells: 359 nCPM
ocular epithelial cells: 336 nCPM

Immune cell

plasmacytoid DC: 202 nTPM
non-classical monocyte: 136 nTPM
myeloid DC: 130 nTPM
naive B-cell: 121 nTPM
memory B-cell: 117 nTPM
eosinophil: 116 nTPM

Brain region

hypothalamus: 103 nTPM
white matter: 90 nTPM
midbrain: 89 nTPM
medulla oblongata: 85 nTPM
pons: 85 nTPM
thalamus: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.35
gnomAD missense Z: 0.5
DepMap mean gene effect: -1.66
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PFDN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PFDN2 as an antibody target. Whether an autoantibody or antibody against PFDN2 could matter depends on whether native PFDN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PFDN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PFDN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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