Seroatlas · Human Serome Atlas

GNG2

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Also known as: GBG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59768
Gene: GNG2
Ensembl: ENSG00000186469
Chromosome: 14
Canonical length: 71 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

71 residues, UniProt reviewed canonical sequence.

>P59768|GNG2
     1  MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP
    61  FREKKFFCAI L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

testis: 107 nTPM
cerebral cortex: 81 nTPM
amygdala: 69 nTPM
hypothalamus: 67 nTPM
thymus: 55 nTPM
bone marrow: 55 nTPM

Single-cell type

neutrophils: 2,004 nCPM
late spermatids: 1,785 nCPM
nk-cells: 1,112 nCPM
early spermatids: 981 nCPM
t-cells: 721 nCPM
sertoli cells: 447 nCPM

Immune cell

basophil: 378 nTPM
neutrophil: 185 nTPM
non-classical monocyte: 176 nTPM
eosinophil: 176 nTPM
gdT-cell: 162 nTPM
total PBMC: 158 nTPM

Brain region

hypothalamus: 171 nTPM
cerebral cortex: 125 nTPM
hippocampal formation: 105 nTPM
basal ganglia: 94 nTPM
amygdala: 92 nTPM
pons: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.51
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G-protein beta-subunit binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG2 as an antibody target. Whether an autoantibody or antibody against GNG2 could matter depends on whether native GNG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG2 is annotated at the cell surface, where native GNG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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