Seroatlas · Human Serome Atlas

PFDN6

Prefoldin subunit 6

Also known as: H2-KE2, HKE2, KE-2, PFD6, PFD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15212
Gene: PFDN6
Ensembl: ENSG00000204220
Chromosome: 6
Canonical length: 129 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>O15212|PFDN6
     1  MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL DGSNVVFKLL
    61  GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ SEQQRETLAQ LQQEFQRAQA
   121  AKAGAPGKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PFDN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 124 nTPM
amygdala: 120 nTPM
cerebral cortex: 115 nTPM
hippocampal formation: 114 nTPM
hypothalamus: 110 nTPM
basal ganglia: 102 nTPM

Single-cell type

oocytes: 244 nCPM
late primary spermatocytes: 193 nCPM
early primary spermatocytes: 131 nCPM
migrating cytotrophoblasts: 105 nCPM
extravillous trophoblasts: 104 nCPM
cytotrophoblasts: 99 nCPM

Immune cell

non-classical monocyte: 3.5 nTPM
plasmacytoid DC: 3.5 nTPM
T-reg: 3.5 nTPM
memory B-cell: 3.3 nTPM
intermediate monocyte: 3.2 nTPM
naive B-cell: 3.2 nTPM

Brain region

cerebral cortex: 12 nTPM
white matter: 11 nTPM
pons: 11 nTPM
midbrain: 10 nTPM
medulla oblongata: 10 nTPM
hypothalamus: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 1.41
DepMap mean gene effect: -1.7
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PFDN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PFDN6 as an antibody target. Whether an autoantibody or antibody against PFDN6 could matter depends on whether native PFDN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PFDN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PFDN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...