Seroatlas · Human Serome Atlas

DYNLT1

Dynein light chain Tctex-type 1

Also known as: DYLT1_HUMAN, TCTEL1, Tctex-1, TCTEX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P63172
Gene
DYNLT1
Ensembl
ENSG00000146425
Chromosome
6
Canonical length
113 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol,Acrosome
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>P63172|DYNLT1
     1  MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT LSQLTKLGKP
    61  FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK TMYCIVSAFG LSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
182 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 182 nTPM
  • kidney: 164 nTPM
  • blood vessel: 160 nTPM
  • fallopian tube: 155 nTPM
  • smooth muscle: 154 nTPM
  • esophagus: 148 nTPM

Single-cell type

  • esophageal apical cells: 1,751 nCPM
  • fallopian tube ciliated cells: 820 nCPM
  • respiratory ciliated cells: 753 nCPM
  • esophageal suprabasal cells: 739 nCPM
  • endometrial ciliated cells: 679 nCPM
  • late primary spermatocytes: 657 nCPM

Immune cell

  • neutrophil: 685 nTPM
  • classical monocyte: 385 nTPM
  • intermediate monocyte: 376 nTPM
  • non-classical monocyte: 292 nTPM
  • total PBMC: 254 nTPM
  • myeloid DC: 193 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • white matter: 44 nTPM
  • medulla oblongata: 42 nTPM
  • midbrain: 40 nTPM
  • hypothalamus: 37 nTPM
  • spinal cord: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.5
gnomAD pLI
0
gnomAD missense Z
-0.27
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNLT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLT1 as an antibody target. Whether an autoantibody or antibody against DYNLT1 could matter depends on whether native DYNLT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNLT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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