Seroatlas · Human Serome Atlas

PFDN4

Prefoldin subunit 4

Also known as: C-1, C1, PFD4, PFD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQP4
Gene: PFDN4
Ensembl: ENSG00000101132
Chromosome: 20
Canonical length: 134 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q9NQP4|PFDN4
     1  MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL EDACDDIMLA
    61  DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA LESRVESIQR VLADLKVQLY
   121  AKFGSNINLE ADES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PFDN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 15 nTPM
amygdala: 14 nTPM
cerebral cortex: 14 nTPM
heart muscle: 13 nTPM
midbrain: 12 nTPM
hippocampal formation: 12 nTPM

Single-cell type

late primary spermatocytes: 410 nCPM
gastric progenitor cells: 355 nCPM
oocytes: 332 nCPM
extravillous trophoblasts: 185 nCPM
esophageal apical cells: 177 nCPM
early spermatids: 173 nCPM

Immune cell

T-reg: 13 nTPM
plasmacytoid DC: 8.6 nTPM
myeloid DC: 7.8 nTPM
NK-cell: 7.6 nTPM
MAIT T-cell: 6.2 nTPM
naive CD4 T-cell: 6.1 nTPM

Brain region

hypothalamus: 9.9 nTPM
midbrain: 8.7 nTPM
cerebral cortex: 8.6 nTPM
pons: 8.2 nTPM
medulla oblongata: 7.4 nTPM
thalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.48
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PFDN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PFDN4 as an antibody target. Whether an autoantibody or antibody against PFDN4 could matter depends on whether native PFDN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PFDN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PFDN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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