Seroatlas · Human Serome Atlas

APOBEC3G

DNA dC->dU-editing enzyme APOBEC-3G

Also known as: ABC3G_HUMAN, bK150C2.7, CEM15, dJ494G10.1, FLJ12740, MDS019

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HC16
Gene
APOBEC3G
Ensembl
ENSG00000239713
Chromosome
22
Canonical length
384 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q9HC16|APOBEC3G
     1  MKPHFRNTVE RMYRDTFSYN FYNRPILSRR NTVWLCYEVK TKGPSRPPLD AKIFRGQVYS
    61  ELKYHPEMRF FHWFSKWRKL HRDQEYEVTW YISWSPCTKC TRDMATFLAE DPKVTLTIFV
   121  ARLYYFWDPD YQEALRSLCQ KRDGPRATMK IMNYDEFQHC WSKFVYSQRE LFEPWNNLPK
   181  YYILLHIMLG EILRHSMDPP TFTFNFNNEP WVRGRHETYL CYEVERMHND TWVLLNQRRG
   241  FLCNQAPHKH GFLEGRHAEL CFLDVIPFWK LDLDQDYRVT CFTSWSPCFS CAQEMAKFIS
   301  KNKHVSLCIF TARIYDDQGR CQEGLRTLAE AGAKISIMTY SEFKHCWDTF VDHQGCPFQP
   361  WDGLDEHSQD LSGRLRAILQ NQEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC3G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 43 nTPM
  • tonsil: 33 nTPM
  • spleen: 29 nTPM
  • thymus: 24 nTPM
  • ovary: 23 nTPM
  • seminal vesicle: 21 nTPM

Single-cell type

  • nk-cells: 166 nCPM
  • t-cells: 104 nCPM
  • plasma cells: 82 nCPM
  • sertoli cells: 61 nCPM
  • early spermatids: 50 nCPM
  • innate lymphoid cells: 46 nCPM

Immune cell

  • gdT-cell: 365 nTPM
  • total PBMC: 298 nTPM
  • memory CD8 T-cell: 282 nTPM
  • NK-cell: 233 nTPM
  • MAIT T-cell: 208 nTPM
  • naive CD8 T-cell: 161 nTPM

Brain region

  • white matter: 4.8 nTPM
  • hypothalamus: 3.9 nTPM
  • spinal cord: 3.7 nTPM
  • medulla oblongata: 3.5 nTPM
  • midbrain: 3.1 nTPM
  • pons: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.67
gnomAD pLI
0
gnomAD missense Z
0.15
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APOBEC3G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBEC3G as an antibody target. Whether an autoantibody or antibody against APOBEC3G could matter depends on whether native APOBEC3G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBEC3G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOBEC3G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APOBEC3G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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