Seroatlas · Human Serome Atlas

LSM14A

Protein LSM14 homolog A

Also known as: C19orf13, DKFZP434D1335, FAM61A, LS14A_HUMAN, RAP55, RAP55A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8ND56
Gene
LSM14A
Ensembl
ENSG00000257103
Chromosome
19
Canonical length
463 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q8ND56|LSM14A
     1  MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP TDRPIPPRDE
    61  VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS STSSFQSMGS YGPFGRMPTY
   121  SQFSPSSLVG QQFGAVGVAG SSLTSFGTET SNSGTLPQSS AVGSAFTQDT RSLKTQLSQG
   181  RSSPQLDPLR KSPTMEQAVQ TASAHLPAPA AVGRRSPVST RPLPSASQKA GENQEHRRAE
   241  VHKVSRPENE QLRNDNKRQV APGAPSAPRR GRGGHRGGRG RFGIRRDGPM KFEKDFDFES
   301  ANAQFNKEEI DREFHNKLKL KEDKLEKQEK PVNGEDKGDS GVDTQNSEGN ADEEDPLGPN
   361  CYYDKTKSFF DNISCDDNRE RRPTWAEERR LNAETFGIPL RPNRGRGGYR GRGGLGFRGG
   421  RGRGGGRGGT FTAPRGFRGG FRGGRGGREF ADFEYRKTTA FGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 70 nTPM
  • bone marrow: 68 nTPM
  • blood vessel: 54 nTPM
  • retina: 49 nTPM
  • ovary: 49 nTPM
  • thymus: 47 nTPM

Single-cell type

  • choroid plexus epithelial cells: 256 nCPM
  • proximal tubule cells: 209 nCPM
  • distal convoluted tubule cells: 207 nCPM
  • loop of henle epithelial cells: 199 nCPM
  • renal connecting tubule cells: 198 nCPM
  • podocytes: 194 nCPM

Immune cell

  • eosinophil: 19 nTPM
  • NK-cell: 18 nTPM
  • basophil: 17 nTPM
  • MAIT T-cell: 15 nTPM
  • non-classical monocyte: 15 nTPM
  • naive CD4 T-cell: 14 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • spinal cord: 16 nTPM
  • cerebral cortex: 15 nTPM
  • cerebellum: 15 nTPM
  • white matter: 14 nTPM
  • midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.04
gnomAD missense Z
1.91
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM14A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM14A as an antibody target. Whether an autoantibody or antibody against LSM14A could matter depends on whether native LSM14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSM14A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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