Seroatlas · Human Serome Atlas

DCP1A

mRNA-decapping enzyme 1A

Also known as: DCP1A_HUMAN, HSA275986, SMAD4IP1, SMIF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPI6
Gene
DCP1A
Ensembl
ENSG00000272886
Chromosome
3
Canonical length
582 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytoplasmic bodies

OverviewNCBI Gene

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>Q9NPI6|DCP1A
     1  MEALSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI EGTLFVYRRS
    61  ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK
   121  LMADVVEEET RRSQQAARDK QSPSQANGCS DHRPIDILEM LSRAKDEYER NQMGDSNISS
   181  PGLQPSTQLS NLGSTETLEE MPSGSQDKSA PSGHKHLTVE ELFGTSLPKE QPAVVGLDSE
   241  EMERLPGDAS QKEPNSFLPF PFEQLGGAPQ SETLGVPSAA HHSVQPEITT PVLITPASIT
   301  QSNEKHAPTY TIPLSPVLSP TLPAEAPTAQ VPPSLPRNST MMQAVKTTPR QRSPLLNQPV
   361  PELSHASLIA NQSPFRAPLN VTNTAGTSLP SVDLLQKLRL TPQHDQIQTQ PLGKGAMVAS
   421  FSPAAGQLAT PESFIEPPSK TAAARVAASA SLSNMVLAPL QSMQQNQDPE VFVQPKVLSS
   481  AIPVAGAPLV TATTTAVSSV LLAPSVFQQT VTRSSDLERK ASSPSPLTIG TPESQRKPSI
   541  ILSKSQLQDT LIHLIKNDSS FLSTLHEVYL QVLTKNKDNH NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 28 nTPM
  • thymus: 13 nTPM
  • ovary: 12 nTPM
  • endometrium: 11 nTPM
  • cerebellum: 10 nTPM
  • parathyroid gland: 9.7 nTPM

Single-cell type

  • neutrophils: 201 nCPM
  • sertoli cells: 171 nCPM
  • adrenal cortex cells: 155 nCPM
  • myonuclei: 134 nCPM
  • extravillous trophoblasts: 132 nCPM
  • neutrophil progenitors: 129 nCPM

Immune cell

  • NK-cell: 55 nTPM
  • non-classical monocyte: 53 nTPM
  • MAIT T-cell: 51 nTPM
  • naive CD4 T-cell: 50 nTPM
  • naive B-cell: 49 nTPM
  • memory CD8 T-cell: 48 nTPM

Brain region

  • cerebellum: 30 nTPM
  • cerebral cortex: 20 nTPM
  • white matter: 19 nTPM
  • choroid plexus: 18 nTPM
  • thalamus: 18 nTPM
  • pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.69
gnomAD missense Z
1.21

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCP1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCP1A as an antibody target. Whether an autoantibody or antibody against DCP1A could matter depends on whether native DCP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCP1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...