Seroatlas · Human Serome Atlas

EDC4

Enhancer of mRNA-decapping protein 4

Also known as: EDC4_HUMAN, Ge-1, HEDLS, RCD-8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P2E9
Gene: EDC4
Ensembl: ENSG00000038358
Chromosome: 16
Canonical length: 1401 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1401 residues, UniProt reviewed canonical sequence.

>Q6P2E9|EDC4
     1  MASCASIDIE DATQHLRDIL KLDRPAGGPS AESPRPSSAY NGDLNGLLVP DPLCSGDSTS
    61  ANKTGLRTMP PINLQEKQVI CLSGDDSSTC IGILAKEVEI VASSDSSISS KARGSNKVKI
   121  QPVAKYDWEQ KYYYGNLIAV SNSFLAYAIR AANNGSAMVR VISVSTSERT LLKGFTGSVA
   181  DLAFAHLNSP QLACLDEAGN LFVWRLALVN GKIQEEILVH IRQPEGTPLN HFRRIIWCPF
   241  IPEESEDCCE ESSPTVALLH EDRAEVWDLD MLRSSHSTWP VDVSQIKQGF IVVKGHSTCL
   301  SEGALSPDGT VLATASHDGY VKFWQIYIEG QDEPRCLHEW KPHDGRPLSC LLFCDNHKKQ
   361  DPDVPFWRFL ITGADQNREL KMWCTVSWTC LQTIRFSPDI FSSVSVPPSL KVCLDLSAEY
   421  LILSDVQRKV LYVMELLQNQ EEGHACFSSI SEFLLTHPVL SFGIQVVSRC RLRHTEVLPA
   481  EEENDSLGAD GTHGAGAMES AAGVLIKLFC VHTKALQDVQ IRFQPQLNPD VVAPLPTHTA
   541  HEDFTFGESR PELGSEGLGS AAHGSQPDLR RIVELPAPAD FLSLSSETKP KLMTPDAFMT
   601  PSASLQQITA SPSSSSSGSS SSSSSSSSSL TAVSAMSSTS AVDPSLTRPP EELTLSPKLQ
   661  LDGSLTMSSS GSLQASPRGL LPGLLPAPAD KLTPKGPGQV PTATSALSLE LQEVEPLGLP
   721  QASPSRTRSP DVISSASTAL SQDIPEIASE ALSRGFGSSA PEGLEPDSMA SAASALHLLS
   781  PRPRPGPELG PQLGLDGGPG DGDRHNTPSL LEAALTQEAS TPDSQVWPTA PDITRETCST
   841  LAESPRNGLQ EKHKSLAFHR PPYHLLQQRD SQDASAEQSD HDDEVASLAS ASGGFGTKVP
   901  APRLPAKDWK TKGSPRTSPK LKRKSKKDDG DAAMGSRLTE HQVAEPPEDW PALIWQQQRE
   961  LAELRHSQEE LLQRLCTQLE GLQSTVTGHV ERALETRHEQ EQRRLERALA EGQQRGGQLQ
  1021  EQLTQQLSQA LSSAVAGRLE RSIRDEIKKT VPPCVSRSLE PMAGQLSNSV ATKLTAVEGS
  1081  MKENISKLLK SKNLTDAIAR AAADTLQGPM QAAYREAFQS VVLPAFEKSC QAMFQQINDS
  1141  FRLGTQEYLQ QLESHMKSRK AREQEAREPV LAQLRGLVST LQSATEQMAA TVAGSVRAEV
  1201  QHQLHVAVGS LQESILAQVQ RIVKGEVSVA LKEQQAAVTS SIMQAMRSAA GTPVPSAHLD
  1261  CQAQQAHILQ LLQQGHLNQA FQQALTAADL NLVLYVCETV DPAQVFGQPP CPLSQPVLLS
  1321  LIQQLASDLG TRTDLKLSYL EEAVMHLDHS DPITRDHMGS VMAQVRQKLF QFLQAEPHNS
  1381  LGKAARRLSL MLHGLVTPSL P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 26 nTPM
choroid plexus: 26 nTPM
bone marrow: 23 nTPM
skeletal muscle: 21 nTPM
thymus: 19 nTPM
testis: 18 nTPM

Single-cell type

brain inhibitory neurons: 17 nCPM
other brain neurons: 16 nCPM
brain excitatory neurons: 15 nCPM
oligodendrocytes: 15 nCPM
epicardial cells: 14 nCPM
oligodendrocyte progenitor cells: 13 nCPM

Immune cell

T-reg: 11 nTPM
non-classical monocyte: 11 nTPM
gdT-cell: 8.9 nTPM
memory CD8 T-cell: 8.4 nTPM
NK-cell: 8.3 nTPM
MAIT T-cell: 7.9 nTPM

Brain region

cerebral cortex: 28 nTPM
white matter: 26 nTPM
basal ganglia: 25 nTPM
cerebellum: 24 nTPM
hypothalamus: 22 nTPM
midbrain: 22 nTPM

ReferencesPubMed · IEDB

Publications for EDC4 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Processing body autoantibodies reconsidered.
2006 · RNA · RCR 0.3 · 17 citations
Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein.
2020 · Clin Chem Lab Med · RCR 0.1 · 3 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.11
gnomAD missense Z: 3.29
DepMap mean gene effect: -0.41
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

deadenylation-independent decapping of nuclear-transcribed mRNA

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
Enhancer of mRNA-decapping protein 4, WD40 repeat region
Enhancer of mRNA-decapping protein 4, conserved C-terminal domain superfamily
Enhancer of mRNA-decapping protein 4-like
Enhancer of mRNA-decapping protein 4, C-terminal
WD40 region of Ge1, enhancer of mRNA-decapping protein
Enhancer of mRNA-decapping protein 4, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EDC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDC4 as an antibody target. Whether an autoantibody or antibody against EDC4 could matter depends on whether native EDC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EDC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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