Seroatlas · Human Serome Atlas

PATL1

Protein PAT1 homolog 1

Also known as: FLJ36874, Pat1b, PATL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TB9
Gene
PATL1
Ensembl
ENSG00000166889
Chromosome
11
Canonical length
770 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytoplasmic bodies

OverviewNCBI Gene

Enables poly(G) binding activity and poly(U) RNA binding activity. Involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in CCR4-NOT complex; P-body; and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>Q86TB9|PATL1
     1  MFRYESLEDC PLDEDEDAFQ GLGEEDEEID QFNDDTFGSG AVDDDWQEAH ERLAELEEKL
    61  PVAVNEQTGN GERDEMDLLG DHEENLAERL SKMVIENELE DPAIMRAVQT RPVLQPQPGS
   121  LNSSIWDGSE VLRRIRGPLL AQEMPTVSVL EYALPQRPPQ GPEDDRDLSE RALPRRSTSP
   181  IIGSPPVRAV PIGTPPKQMA VPSFTQQILC PKPVHVRPPM PPRYPAPYGE RMSPNQLCSV
   241  PNSSLLGHPF PPSVPPVLSP LQRAQLLGGA QLQPGRMSPS QFARVPGFVG SPLAAMNPKL
   301  LQGRVGQMLP PAPGFRAFFS APPSATPPPQ QHPPGPGPHL QNLRSQAPMF RPDTTHLHPQ
   361  HRRLLHQRQQ QNRSQHRNLN GAGDRGSHRS SHQDHLRKDP YANLMLQREK DWVSKIQMMQ
   421  LQSTDPYLDD FYYQNYFEKL EKLSAAEEIQ GDGPKKERTK LITPQVAKLE HAYKPVQFEG
   481  SLGKLTVSSV NNPRKMIDAV VTSRSEDDET KEKQVRDKRR KTLVIIEKTY SLLLDVEDYE
   541  RRYLLSLEEE RPALMDDRKH KICSMYDNLR GKLPGQERPS DDHFVQIMCI RKGKRMVARI
   601  LPFLSTEQAA DILMTTARNL PFLIKKDAQD EVLPCLLSPF SLLLYHLPSV SITSLLRQLM
   661  NLPQSAATPA LSNPHLTAVL QNKFGLSLLL ILLSRGEDLQ SSDPATESTQ NNQWTEVMFM
   721  ATRELLRIPQ AALAKPISIP TNLVSLFSRY VDRQKLNLLE TKLQLVQGIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PATL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 54 nTPM
  • skeletal muscle: 38 nTPM
  • liver: 31 nTPM
  • tongue: 31 nTPM
  • tonsil: 22 nTPM
  • retina: 22 nTPM

Single-cell type

  • neutrophils: 193 nCPM
  • neutrophil progenitors: 89 nCPM
  • kupffer cells: 70 nCPM
  • endometrial glandular cells: 61 nCPM
  • gastric progenitor cells: 55 nCPM
  • endometrial stromal cells: 54 nCPM

Immune cell

  • eosinophil: 3.4 nTPM
  • neutrophil: 3.4 nTPM
  • non-classical monocyte: 2.9 nTPM
  • intermediate monocyte: 2.8 nTPM
  • gdT-cell: 2.7 nTPM
  • classical monocyte: 2.4 nTPM

Brain region

  • white matter: 25 nTPM
  • choroid plexus: 22 nTPM
  • medulla oblongata: 22 nTPM
  • thalamus: 22 nTPM
  • pons: 21 nTPM
  • cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.96
gnomAD missense Z
2.44
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PATL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PATL1 as an antibody target. Whether an autoantibody or antibody against PATL1 could matter depends on whether native PATL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PATL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PATL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PATL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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