Seroatlas · Human Serome Atlas

LIMD1

LIM domain-containing protein 1

Also known as: LIMD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UGP4
Gene
LIMD1
Ensembl
ENSG00000144791
Chromosome
3
Canonical length
676 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Focal adhesion sites

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; negative regulation of macromolecule biosynthetic process; and response to hypoxia. Acts upstream of or within P-body assembly and miRNA-mediated post-transcriptional gene silencing. Located in several cellular components, including P-body; adherens junction; and focal adhesion. Part of RISC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

676 residues, UniProt reviewed canonical sequence.

>Q9UGP4|LIMD1
     1  MDKYDDLGLE ASKFIEDLNM YEASKDGLFR VDKGAGNNPE FEETRRVFAT KMAKIHLQQQ
    61  QQQLLQEETL PRGSRGPVNG GGRLGPQARW EVVGSKLTVD GAAKPPLAAS TGAPGAVTTL
   121  AAGQPPYPPQ EQRSRPYLHG TRHGSQDCGS RESLATSEMS AFHQPGPCED PSCLTHGDYY
   181  DNLSLASPKW GDKPGVSPSI GLSVGSGWPS SPGSDPPLPK PCGDHPLNHR QLSLSSSRSS
   241  EGSLGGQNSG IGGRSSEKPT GLWSTASSQR VSPGLPSPNL ENGAPAVGPV QPRTPSVSAP
   301  LALSCPRQGG LPRSNSGLGG EVSGVMSKPN VDPQPWFQDG PKSYLSSSAP SSSPAGLDGS
   361  QQGAVPGLGP KPGCTDLGTG PKLSPTSLVH PVMSTLPELS CKEGPLGWSS DGSLGSVLLD
   421  SPSSPRVRLP CQPLVPGPEL RPSAAELKLE ALTQRLEREM DAHPKADYFG ACVKCSKGVF
   481  GAGQACQAMG NLYHDTCFTC AACSRKLRGK AFYFVNGKVF CEEDFLYSGF QQSADRCFLC
   541  GHLIMDMILQ ALGKSYHPGC FRCVICNECL DGVPFTVDSE NKIYCVRDYH KVLAPKCAAC
   601  GLPILPPEGS DETIRVVSMD RDYHVECYHC EDCGLELNDE DGHRCYPLED HLFCHSCHVK
   661  RLEKRPSSTA LHQHHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • lung: 16 nTPM
  • skeletal muscle: 14 nTPM
  • thyroid gland: 11 nTPM
  • spleen: 10 nTPM
  • lymph node: 9.7 nTPM
  • pancreas: 9.4 nTPM

Single-cell type

  • alveolar cells type 1: 219 nCPM
  • tuft cells: 185 nCPM
  • transitional alveolar cells: 179 nCPM
  • oligodendrocyte progenitor cells: 144 nCPM
  • pdcs: 130 nCPM
  • retinal pigment epithelial cells: 119 nCPM

Immune cell

  • plasmacytoid DC: 5.7 nTPM
  • naive B-cell: 4 nTPM
  • non-classical monocyte: 4 nTPM
  • basophil: 3.8 nTPM
  • memory B-cell: 2.3 nTPM
  • intermediate monocyte: 2 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • medulla oblongata: 24 nTPM
  • white matter: 22 nTPM
  • thalamus: 21 nTPM
  • pons: 21 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.42
gnomAD missense Z
0.48
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIMD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIMD1 as an antibody target. Whether an autoantibody or antibody against LIMD1 could matter depends on whether native LIMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIMD1 is annotated at the cell surface, where native LIMD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIMD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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