Seroatlas · Human Serome Atlas

MCRIP1

Mapk-regulated corepressor-interacting protein 1

Also known as: FAM195B, GRAN2, MCRI1_HUMAN, MCRIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JLW8
Gene: MCRIP1
Ensembl: ENSG00000225663
Chromosome: 17
Canonical length: 97 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in regulation of epithelial to mesenchymal transition. Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>C9JLW8|MCRIP1
     1  MTSSPVSRVV YNGKRTSSPR SPPSSSEIFT PAHEENVRFI YEAWQGVERD LRGQVPGGER
    61  GLVEEYVEKV PNPSLKTFKP IDLSDLKRRS TQDAKKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCRIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 171 nTPM

Expression across tissuesHPA

Tissue

amygdala: 171 nTPM
cerebral cortex: 167 nTPM
testis: 162 nTPM
midbrain: 150 nTPM
hippocampal formation: 148 nTPM
spinal cord: 142 nTPM

Single-cell type

late spermatids: 49 nCPM
podocytes: 33 nCPM
oligodendrocytes: 28 nCPM
other brain neurons: 27 nCPM
proximal tubule cells: 26 nCPM
bergmann glia: 23 nCPM

Immune cell

basophil: 66 nTPM
non-classical monocyte: 47 nTPM
eosinophil: 46 nTPM
intermediate monocyte: 43 nTPM
total PBMC: 40 nTPM
plasmacytoid DC: 40 nTPM

Brain region

medulla oblongata: 81 nTPM
thalamus: 80 nTPM
midbrain: 77 nTPM
pons: 75 nTPM
amygdala: 75 nTPM
cerebral cortex: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.04
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCRIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCRIP1 as an antibody target. Whether an autoantibody or antibody against MCRIP1 could matter depends on whether native MCRIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCRIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCRIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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