Seroatlas · Human Serome Atlas

WTIP

Wilms tumor protein 1-interacting protein

Also known as: WTIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NIX2
Gene: WTIP
Ensembl: ENSG00000142279
Chromosome: 19
Canonical length: 430 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and response to hypoxia. Acts upstream of or within miRNA-mediated post-transcriptional gene silencing. Located in P-body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>A6NIX2|WTIP
     1  MQRSRAGADE AALLLAGLAL RELEPGCGSP GRGRRGPRPG PGDEAAPALG RRGKGSGGPE
    61  AGADGLSRGE RGPRRAAVPE LSAQPAGSPR ASLAGSDGGG GGGSARSSGI SLGYDQRHGS
   121  PRSGRSDPRP GPGPPSVGSA RSSVSSLGSR GSAGAYADFL PPGACPAPAR SPEPAGPAPF
   181  PLPALPLPPG REGGPSAAER RLEALTRELE RALEARTARD YFGICIKCGL GIYGAQQACQ
   241  AMGSLYHTDC FTCDSCGRRL RGKAFYNVGE KVYCQEDFLY SGFQQTADKC SVCGHLIMEM
   301  ILQALGKSYH PGCFRCSVCN ECLDGVPFTV DVENNIYCVR DYHTVFAPKC ASCARPILPA
   361  QGCETTIRVV SMDRDYHVAC YHCEDCGLQL SGEEGRRCYP LAGHLLCRRC HLRRLQPGPL
   421  PSPTVHVTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WTIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 93 nTPM
ovary: 30 nTPM
adipose tissue: 23 nTPM
tongue: 22 nTPM
cervix: 20 nTPM
heart muscle: 19 nTPM

Single-cell type

vascular smooth muscle cells: 232 nCPM
alveolar cells type 1: 129 nCPM
late spermatids: 79 nCPM
early spermatids: 66 nCPM
transitional alveolar cells: 61 nCPM
pericytes: 52 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.6 nTPM
classical monocyte: 0.2 nTPM
naive B-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

choroid plexus: 19 nTPM
cerebellum: 16 nTPM
amygdala: 15 nTPM
cerebral cortex: 15 nTPM
basal ganglia: 14 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WTIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WTIP as an antibody target. Whether an autoantibody or antibody against WTIP could matter depends on whether native WTIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WTIP is annotated at the cell surface, where native WTIP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WTIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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