Seroatlas · Human Serome Atlas

LSM14B

Protein LSM14 homolog B

Also known as: bA11M20.3, C20orf40, FAM61B, FLJ25473, FT005, LS14B_HUMAN, LSM13, RAP55B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BX40
Gene
LSM14B
Ensembl
ENSG00000149657
Chromosome
20
Canonical length
385 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in several processes, including maternal mRNA clearance; meiotic cell cycle process involved in oocyte maturation; and ovarian follicle development. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q9BX40|LSM14B
     1  MSGSSGTPYL GSKISLISKA QIRYEGILYT IDTDNSTVAL AKVRSFGTED RPTDRPAPPR
    61  EEIYEYIIFR GSDIKDITVC EPPKAQHTLP QDPAIVQSSL GSASASPFQP HVPYSPFRGM
   121  APYGPLAASS LLSQQYAASL GLGAGFPSIP VGKSPMVEQA VQTGSADNLN AKKLLPGKGT
   181  TGTQLNGRQA QPSSKTASDV VQPAAVQAQG QVNDENRRPQ RRRSGNRRTR NRSRGQNRPT
   241  NVKENTIKFE GDFDFESANA QFNREELDKE FKKKLNFKDD KAEKGEEKDL AVVTQSAEAP
   301  AEEDLLGPNC YYDKSKSFFD NISSELKTSS RRTTWAEERK LNTETFGVSG RFLRGRSSRG
   361  GFRGGRGNGT TRRNPTSHRA GTGRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM14B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 70 nTPM
  • skeletal muscle: 67 nTPM
  • testis: 49 nTPM
  • tongue: 42 nTPM
  • cerebral cortex: 39 nTPM
  • heart muscle: 35 nTPM

Single-cell type

  • late spermatids: 902 nCPM
  • early spermatids: 287 nCPM
  • megakaryocytes: 37 nCPM
  • late primary spermatocytes: 37 nCPM
  • medullary thymic epithelial cells: 31 nCPM
  • thymic myoid cells: 26 nCPM

Immune cell

  • eosinophil: 2.3 nTPM
  • neutrophil: 0.6 nTPM
  • memory B-cell: 0.5 nTPM
  • naive B-cell: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • cerebellum: 85 nTPM
  • cerebral cortex: 70 nTPM
  • hippocampal formation: 66 nTPM
  • basal ganglia: 64 nTPM
  • amygdala: 60 nTPM
  • thalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.69
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM14B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM14B as an antibody target. Whether an autoantibody or antibody against LSM14B could matter depends on whether native LSM14B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM14B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM14B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSM14B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...