Seroatlas · Human Serome Atlas

DCP1B

mRNA-decapping enzyme 1B

Also known as: DCP1B_HUMAN, FLJ31638

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZD4
Gene: DCP1B
Ensembl: ENSG00000151065
Chromosome: 12
Canonical length: 617 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q8IZD4|DCP1B
     1  MAAVAAGGLV GKGRDISLAA LQRHDPYINR IVDVASQVAL YTFGHRANEW EKTDVEGTLF
    61  VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQDPFL LYRNARLSIY GIWFYDKEEC
   121  QRIAELMKNL TQYEQLKAHQ GTGAGISPVI LNSGEGKEVD ILRMLIKAKD EYTKCKTCSE
   181  PKKITSSSAI YDNPNLIKPI PVKPSENQQQ RIPQPNQTLD PEPQHLSLTA LFGKQDKATC
   241  QETVEPPQTL HQQQQQQQQQ QEKLPIRQGV VRSLSYEEPR RHSPPIEKQL CPAIQKLMVR
   301  SADLHPLSEL PENRPCENGS THSAGEFFTG PVQPGSPHNI GTSRGVQNAS RTQNLFEKLQ
   361  STPGAANKCD PSTPAPASSA ALNRSRAPTS VTPVAPGKGL AQPPQAYFNG SLPPQTVGHQ
   421  AHGREQSTLP RQTLPISGSQ TGSSGVISPQ ELLKKLQIVQ QEQQLHASNR PALAAKFPVL
   481  AQSSGTGKPL ESWINKTPNT EQQTPLFQVI SPQRIPATAA PSLLMSPMVF AQPTSVPPKE
   541  RESGLLPVGG QEPPAAATSL LLPIQSPEPS VITSSPLTKL QLQEALLYLI QNDDNFLNII
   601  YEAYLFSMTQ AAMKKTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

colon: 26 nTPM
endometrium: 22 nTPM
testis: 20 nTPM
urinary bladder: 20 nTPM
blood vessel: 18 nTPM
adrenal gland: 16 nTPM

Single-cell type

choroid plexus epithelial cells: 102 nCPM
bergmann glia: 99 nCPM
astrocytes: 55 nCPM
ependymal cells: 52 nCPM
distal convoluted tubule cells: 51 nCPM
oligodendrocyte progenitor cells: 48 nCPM

Immune cell

T-reg: 27 nTPM
MAIT T-cell: 13 nTPM
memory CD4 T-cell: 10 nTPM
naive CD8 T-cell: 10 nTPM
gdT-cell: 10 nTPM
memory CD8 T-cell: 9.8 nTPM

Brain region

cerebral cortex: 6.9 nTPM
choroid plexus: 6.9 nTPM
hypothalamus: 6.1 nTPM
amygdala: 5.6 nTPM
basal ganglia: 5.6 nTPM
white matter: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCP1B as an antibody target. Whether an autoantibody or antibody against DCP1B could matter depends on whether native DCP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCP1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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