Seroatlas · Human Serome Atlas

EIF4ENIF1

Eukaryotic translation initiation factor 4E transporter

Also known as: 2610509L04Rik, 4E-T, 4ET_HUMAN, Clast4, FLJ21601

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRA8
Gene
EIF4ENIF1
Ensembl
ENSG00000184708
Chromosome
22
Canonical length
985 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

985 residues, UniProt reviewed canonical sequence.

>Q9NRA8|EIF4ENIF1
     1  MDRRSMGETE SGDAFLDLKK PPASKCPHRY TKEELLDIKE LPHSKQRPSC LSEKYDSDGV
    61  WDPEKWHASL YPASGRSSPV ESLKKELDTD RPSLVRRIVD PRERVKEDDL DVVLSPQRRS
   121  FGGGCHVTAA VSSRRSGSPL EKDSDGLRLL GGRRIGSGRI ISARTFEKDH RLSDKDLRDL
   181  RDRDRERDFK DKRFRREFGD SKRVFGERRR NDSYTEEEPE WFSAGPTSQS ETIELTGFDD
   241  KILEEDHKGR KRTRRRTASV KEGIVECNGG VAEEDEVEVI LAQEPAADQE VPRDAVLPEQ
   301  SPGDFDFNEF FNLDKVPCLA SMIEDVLGEG SVSASRFSRW FSNPSRSGSR SSSLGSTPHE
   361  ELERLAGLEQ AILSPGQNSG NYFAPIPLED HAENKVDILE MLQKAKVDLK PLLSSLSANK
   421  EKLKESSHSG VVLSVEEVEA GLKGLKVDQQ VKNSTPFMAE HLEETLSAVT NNRQLKKDGD
   481  MTAFNKLVST MKASGTLPSQ PKVSRNLESH LMSPAEIPGQ PVPKNILQEL LGQPVQRPAS
   541  SNLLSGLMGS LEPTTSLLGQ RAPSPPLSQV FQTRAASADY LRPRIPSPIG FTPGPQQLLG
   601  DPFQGMRKPM SPITAQMSQL ELQQAALEGL ALPHDLAVQA ANFYQPGFGK PQVDRTRDGF
   661  RNRQQRVTKS PAPVHRGNSS SPAPAASITS MLSPSFTPTS VIRKMYESKE KSKEEPASGK
   721  AALGDSKEDT QKASEENLLS SSSVPSADRD SSPTTNSKLS ALQRSSCSTP LSQANRYTKE
   781  QDYRPKATGR KTPTLASPVP TTPFLRPVHQ VPLVPHVPMV RPAHQLHPGL VQRMLAQGVH
   841  PQHLPSLLQT GVLPPGMDLS HLQGISGPIL GQPFYPLPAA SHPLLNPRPG TPLHLAMVQQ
   901  QLQRSVLHPP GSGSHAAAVS VQTTPQNVPS RSGLPHMHSQ LEHRPSQRSS SPVGLAKWFG
   961  SDVLQQPLPS MPAKVISVDE LEYRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4ENIF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • testis: 32 nTPM
  • skeletal muscle: 19 nTPM
  • colon: 18 nTPM
  • blood vessel: 17 nTPM
  • retina: 17 nTPM
  • parathyroid gland: 16 nTPM

Single-cell type

  • late spermatids: 156 nCPM
  • oocytes: 129 nCPM
  • myonuclei: 80 nCPM
  • cardiomyocytes: 78 nCPM
  • late primary spermatocytes: 76 nCPM
  • adrenal cortex cells: 69 nCPM

Immune cell

  • non-classical monocyte: 8.2 nTPM
  • memory B-cell: 4.8 nTPM
  • plasmacytoid DC: 4.4 nTPM
  • MAIT T-cell: 3.5 nTPM
  • gdT-cell: 3.4 nTPM
  • memory CD8 T-cell: 3.3 nTPM

Brain region

  • cerebellum: 43 nTPM
  • cerebral cortex: 41 nTPM
  • white matter: 37 nTPM
  • midbrain: 34 nTPM
  • hypothalamus: 33 nTPM
  • basal ganglia: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
1.99
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Eukaryotic translation initiation factor 4E binding protein
  • Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4ENIF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4ENIF1 as an antibody target. Whether an autoantibody or antibody against EIF4ENIF1 could matter depends on whether native EIF4ENIF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4ENIF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4ENIF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF4ENIF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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