YWHAG
14-3-3 protein gamma
Also known as: 14-3-3GAMMA, 1433G_HUMAN, PPP1R170
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P61981
- Gene
- YWHAG
- Ensembl
- ENSG00000170027
- Chromosome
- 7
- Canonical length
- 247 aa
- Protein class
- Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
247 residues, UniProt reviewed canonical sequence.
>P61981|YWHAG
1 MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW
61 RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK
121 VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS
181 VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD
241 DGGEGNNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YWHAG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 355 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 355 nTPM
- skeletal muscle: 328 nTPM
- tongue: 223 nTPM
- hypothalamus: 196 nTPM
- adipose tissue: 177 nTPM
- hippocampal formation: 171 nTPM
Single-cell type
- basal keratinocytes: 352 nCPM
- suprabasal keratinocytes: 318 nCPM
- ocular epithelial cells: 307 nCPM
- gastric progenitor cells: 251 nCPM
- urothelial cells: 245 nCPM
- pancreatic acinar cells: 238 nCPM
Immune cell
- plasmacytoid DC: 2.6 nTPM
- myeloid DC: 2.4 nTPM
- classical monocyte: 2.3 nTPM
- intermediate monocyte: 2 nTPM
- non-classical monocyte: 1.8 nTPM
- basophil: 1.5 nTPM
Brain region
- cerebral cortex: 826 nTPM
- hypothalamus: 576 nTPM
- pons: 561 nTPM
- white matter: 537 nTPM
- medulla oblongata: 519 nTPM
- basal ganglia: 506 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about YWHAG.
Disease | AllUniProt
Conditions YWHAG is implicated in, by any mechanism.
- Developmental and epileptic encephalopathy 56 (DEE56) MIM:617665
Disease | GeneticClinVar
31 pathogenic / likely-pathogenic of 232 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Developmental and epileptic encephalopathy, 56
- Inborn genetic diseases
- YWHAG-related disorder
- 8 conditions
- Bilateral tonic-clonic seizure
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.29
- gnomAD pLI
- 0.96
- gnomAD missense Z
- 2.95
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to glucose starvation
- cellular response to insulin stimulus
- intracellular protein localization
- negative regulation of protein kinase activity
- negative regulation of TORC1 signaling
- positive regulation of cell-cell adhesion
- positive regulation of T cell activation
- positive regulation of T cell mediated immune response to tumor cell
- protein targeting
- regulation of neuron differentiation
- regulation of protein localization
- regulation of signal transduction
- regulation of synaptic plasticity
- signal transduction
Molecular functions
- identical protein binding
- insulin-like growth factor receptor binding
- phosphorylation-dependent protein binding
- protein domain specific binding
- protein kinase C binding
- protein kinase C inhibitor activity
- protein sequestering activity
- receptor tyrosine kinase binding
- RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of YWHAG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YWHAG as an antibody target. Whether an autoantibody or antibody against YWHAG could matter depends on whether native YWHAG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YWHAG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YWHAG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...