Seroatlas · Human Serome Atlas

MCRIP2

MAPK regulated corepressor interacting protein 2

Also known as: C16orf14, FAM195A, MCRI2_HUMAN, MGC15416

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUT9
Gene: MCRIP2
Ensembl: ENSG00000172366
Chromosome: 16
Canonical length: 160 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q9BUT9|MCRIP2
     1  MYTITKGPSK LVAQRRTGPT QQQVEGRLGE LLKCRQPAPP TSQPPRAQPF AQPPGPWPLS
    61  SPGPRLVFNR VNGRRAPSTS PSFEGTQETY TVAHEENVRF VSEAWQQVQQ QLDGGPAGEG
   121  GPRPVQYVER TPNPRLQNFV PIDLDEWWAQ QFLARITSCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCRIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

liver: 57 nTPM
heart muscle: 47 nTPM
skeletal muscle: 40 nTPM
adrenal gland: 32 nTPM
kidney: 24 nTPM
colon: 20 nTPM

Single-cell type

late spermatids: 994 nCPM
late primary spermatocytes: 262 nCPM
cytotrophoblasts: 246 nCPM
enterocytes: 245 nCPM
hepatocytes: 236 nCPM
colonocytes: 230 nCPM

Immune cell

non-classical monocyte: 15 nTPM
intermediate monocyte: 13 nTPM
classical monocyte: 11 nTPM
memory B-cell: 11 nTPM
myeloid DC: 10 nTPM
naive B-cell: 6.9 nTPM

Brain region

choroid plexus: 42 nTPM
cerebellum: 21 nTPM
thalamus: 19 nTPM
pons: 17 nTPM
cerebral cortex: 17 nTPM
amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.37
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCRIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCRIP2 as an antibody target. Whether an autoantibody or antibody against MCRIP2 could matter depends on whether native MCRIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCRIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCRIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...