ATP-dependent RNA helicase DEAD-box, conserved site
IPR000629
Definition
A number of eukaryotic and prokaryotic proteins involved in ATP-dependent, nucleic-acid unwinding have been characterised [[cite:PMID:1552844], [cite:PMID:2563148], [cite:PMID:1825133]] on the basis of their structural similarity. All these proteins share a number of conserved sequence motifs. Some of them are specific to this family while others are shared by other ATP-binding proteins or by proteins belonging to the helicases `superfamily'. One of these motifs, called the 'D-E-A-D-box', represents a special version of the B motif of ATP-binding proteins. Proteins currently known to belong to this family include eukaryotic initiation factor eIF-4A; yeast PRP5, PRP28 and MSS116 splicing proteins, and proteins DHH1, DRS1, MAK5 and ROK1; mouse Pl10, Caenorhabditis elegans helicase glh-1; Drosophila Rm62 (p62), Me31B and Vasa; and Escherichia coli putative RNA helicases dbpA, deaD, rhlB and rhlE.
27 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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