Seroatlas · Human Serome Atlas

AJUBA

LIM domain-containing protein ajuba

Also known as: AJUBA_HUMAN, JUB, MGC15563

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96IF1
Gene
AJUBA
Ensembl
ENSG00000129474
Chromosome
14
Canonical length
538 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and regulation of cellular response to hypoxia. Acts upstream of or within miRNA-mediated post-transcriptional gene silencing and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q96IF1|AJUBA
     1  MERLGEKASR LLEKFGRRKG ESSRSGSDGT PGPGKGRLSG LGGPRKSGPR GATGGPGDEP
    61  LEPAREQGSL DAERNQRGSF EAPRYEGSFP AGPPPTRALP LPQSLPPDFR LEPTAPALSP
   121  RSSFASSSAS DASKPSSPRG SLLLDGAGAG GAGGSRPCSN RTSGISMGYD QRHGSPLPAG
   181  PCLFGPPLAG APAGYSPGGV PSAYPELHAA LDRLYAQRPA GFGCQESRHS YPPALGSPGA
   241  LAGAGVGAAG PLERRGAQPG RHSVTGYGDC AVGARYQDEL TALLRLTVGT GGREAGARGE
   301  PSGIEPSGLE EPPGPFVPEA ARARMREPEA REDYFGTCIK CNKGIYGQSN ACQALDSLYH
   361  TQCFVCCSCG RTLRCKAFYS VNGSVYCEED YLFSGFQEAA EKCCVCGHLI LEKILQAMGK
   421  SYHPGCFRCI VCNKCLDGIP FTVDFSNQVY CVTDYHKNYA PKCAACGQPI LPSEGCEDIV
   481  RVISMDRDYH FECYHCEDCR MQLSDEEGCC CFPLDGHLLC HGCHMQRLNA RQPPANYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AJUBA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • skin: 58 nTPM
  • liver: 41 nTPM
  • placenta: 18 nTPM
  • esophagus: 17 nTPM
  • kidney: 17 nTPM
  • vagina: 15 nTPM

Single-cell type

  • tuft cells: 12 nCPM
  • ependymal cells: 9.8 nCPM
  • choroid plexus epithelial cells: 7.1 nCPM
  • endometrial secretory cells: 6.2 nCPM
  • alveolar cells type 1: 2.5 nCPM
  • late primary spermatocytes: 2.5 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • NK-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • white matter: 6.5 nTPM
  • medulla oblongata: 6.3 nTPM
  • amygdala: 5.7 nTPM
  • spinal cord: 5.7 nTPM
  • hippocampal formation: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.8
gnomAD missense Z
2.25
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AJUBA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AJUBA as an antibody target. Whether an autoantibody or antibody against AJUBA could matter depends on whether native AJUBA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AJUBA is annotated at the cell surface, where native AJUBA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AJUBA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AJUBA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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