Seroatlas · Human Serome Atlas

EED

Polycomb protein EED

Also known as: EED_HUMAN, HEED, WAIT-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75530
Gene
EED
Ensembl
ENSG00000074266
Chromosome
11
Canonical length
441 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>O75530|EED
     1  MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP
    61  NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR
   121  VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM
   181  QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL
   241  SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS
   301  TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ
   361  CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR
   421  DSSILIAVCD DASIWRWDRL R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EED can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 30 nTPM
  • lymph node: 27 nTPM
  • thymus: 17 nTPM
  • appendix: 15 nTPM
  • cerebellum: 15 nTPM
  • retina: 15 nTPM

Single-cell type

  • microglia: 91 nCPM
  • migrating cytotrophoblasts: 75 nCPM
  • cytotrophoblasts: 59 nCPM
  • cdc: 55 nCPM
  • extravillous trophoblasts: 55 nCPM
  • adrenal medulla cells: 53 nCPM

Immune cell

  • T-reg: 59 nTPM
  • naive B-cell: 48 nTPM
  • memory B-cell: 45 nTPM
  • memory CD4 T-cell: 33 nTPM
  • memory CD8 T-cell: 32 nTPM
  • basophil: 31 nTPM

Brain region

  • cerebellum: 17 nTPM
  • hypothalamus: 14 nTPM
  • white matter: 14 nTPM
  • cerebral cortex: 13 nTPM
  • medulla oblongata: 13 nTPM
  • basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EED.

Disease | AllUniProt

Conditions EED is implicated in, by any mechanism.

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 175 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.73
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EED in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EED as an antibody target. Whether an autoantibody or antibody against EED could matter depends on whether native EED is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EED is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EED as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EED. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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