Seroatlas · Human Serome Atlas

MAPK6

Mitogen-activated protein kinase 6

Also known as: ERK3, HsT17250, MK06_HUMAN, p97MAPK, PRKM6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16659
Gene: MAPK6
Ensembl: ENSG00000069956
Chromosome: 15
Canonical length: 721 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Microtubules,Primary cilium,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

721 residues, UniProt reviewed canonical sequence.

>Q16659|MAPK6
     1  MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK
    61  HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE
   121  QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP
   181  HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ
   241  MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS
   301  PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC
   361  QFSEHDWPVH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS
   421  TEPCWQYSDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK
   481  EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLAGKERE KNQGFDFDSF IAGTIQLSSQ
   541  HEPTDVVDKL NDLNSSVSQL ELKSLISKSV SQEKQEKGMA NLAQLEALYQ SSWDSQFVSG
   601  GEDCFFINQF CEVRKDEQVE KENTYTSYLD KFFSRKEDTE MLETEPVEDG KLGERGHEEG
   661  FLNNSGEFLF NKQLESIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH QTYSSILKHL
   721  N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

liver: 33 nTPM
tongue: 31 nTPM
bone marrow: 31 nTPM
testis: 28 nTPM
esophagus: 27 nTPM
skeletal muscle: 26 nTPM

Single-cell type

endometrial glandular cells: 401 nCPM
mast cells: 378 nCPM
late spermatids: 355 nCPM
esophageal apical cells: 341 nCPM
urothelial cells: 300 nCPM
neutrophils: 263 nCPM

Immune cell

T-reg: 4.3 nTPM
NK-cell: 3.7 nTPM
memory CD4 T-cell: 2.8 nTPM
naive CD4 T-cell: 2.6 nTPM
classical monocyte: 2.5 nTPM
memory B-cell: 2.5 nTPM

Brain region

cerebellum: 33 nTPM
cerebral cortex: 30 nTPM
white matter: 27 nTPM
basal ganglia: 26 nTPM
midbrain: 25 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.7
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK6 as an antibody target. Whether an autoantibody or antibody against MAPK6 could matter depends on whether native MAPK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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