Seroatlas · Human Serome Atlas

PDCD5

Programmed cell death protein 5

Also known as: MGC9294, PDCD5_HUMAN, TFAR19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14737
Gene: PDCD5
Ensembl: ENSG00000105185
Chromosome: 19
Canonical length: 125 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>O14737|PDCD5
     1  MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHREAEMR NSILAQVLDQ SARARLSNLA
    61  LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS QQTEKTTTVK FNRRKVMDSD
   121  EDDDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 238 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 238 nTPM
heart muscle: 207 nTPM
testis: 155 nTPM
amygdala: 151 nTPM
cerebral cortex: 136 nTPM
hypothalamus: 130 nTPM

Single-cell type

oocytes: 5,789 nCPM
late primary spermatocytes: 712 nCPM
late spermatids: 677 nCPM
esophageal suprabasal cells: 440 nCPM
early spermatids: 435 nCPM
differentiating spermatogonia: 435 nCPM

Immune cell

T-reg: 219 nTPM
non-classical monocyte: 199 nTPM
memory CD4 T-cell: 168 nTPM
intermediate monocyte: 149 nTPM
memory B-cell: 148 nTPM
MAIT T-cell: 135 nTPM

Brain region

thalamus: 60 nTPM
hypothalamus: 53 nTPM
white matter: 49 nTPM
cerebral cortex: 48 nTPM
pons: 48 nTPM
midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.46
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PDCD5-like
PDCD5-like superfamily
Double-stranded DNA-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD5 as an antibody target. Whether an autoantibody or antibody against PDCD5 could matter depends on whether native PDCD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...