Seroatlas · Human Serome Atlas

TXNDC9

Thioredoxin domain-containing protein 9

Also known as: APACD, TXND9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14530
Gene: TXNDC9
Ensembl: ENSG00000115514
Chromosome: 2
Canonical length: 226 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>O14530|TXNDC9
     1  MEADASVDMF SKVLEHQLLQ TTKLVEEHLD SEIQKLDQMD EDELERLKEK RLQALRKAQQ
    61  QKQEWLSKGH GEYREIPSER DFFQEVKESE NVVCHFYRDS TFRCKILDRH LAILSKKHLE
   121  TKFLKLNVEK APFLCERLHI KVIPTLALLK DGKTQDYVVG FTDLGNTDDF TTETLEWRLG
   181  SSDILNYSGN LMEPPFQNQK KFGTNFTKLE KKTIRGKKYD SDSDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNDC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

tonsil: 32 nTPM
lymph node: 27 nTPM
breast: 27 nTPM
kidney: 27 nTPM
heart muscle: 27 nTPM
liver: 25 nTPM

Single-cell type

late primary spermatocytes: 149 nCPM
esophageal apical cells: 149 nCPM
cardiomyocytes: 143 nCPM
oocytes: 143 nCPM
megakaryocytes: 130 nCPM
extravillous trophoblasts: 108 nCPM

Immune cell

basophil: 111 nTPM
T-reg: 92 nTPM
total PBMC: 87 nTPM
non-classical monocyte: 83 nTPM
NK-cell: 78 nTPM
MAIT T-cell: 70 nTPM

Brain region

white matter: 17 nTPM
pons: 16 nTPM
spinal cord: 16 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 15 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.38
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule cytoskeleton organization

Molecular functions

cadherin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXNDC9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNDC9 as an antibody target. Whether an autoantibody or antibody against TXNDC9 could matter depends on whether native TXNDC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNDC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNDC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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