Seroatlas · Protein domains
BTB/POZ domain
PF02214
Definition
In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels PMID:9886290. In KCTD1 ([swissprot:Q719H9]) this domain functions as a transcriptional repressor PMID:18358072. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [[cite:PMID:18358072],[cite:PMID:19115315]].
50 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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