Seroatlas · Human Serome Atlas

ZDHHC17

Palmitoyltransferase ZDHHC17

Also known as: HIP14, HYPH, KIAA0946, ZDH17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUH5
Gene
ZDHHC17
Ensembl
ENSG00000186908
Chromosome
12
Canonical length
632 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables identical protein binding activity and protein-cysteine S-palmitoyltransferase activity. Involved in lipoprotein transport; protein palmitoylation; and regulation of programmed cell death. Located in Golgi membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>Q8IUH5|ZDHHC17
     1  MQREEGFNTK MADGPDEYDT EAGCVPLLHP EEIKPQSHYN HGYGEPLGRK THIDDYSTWD
    61  IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN NRIDLVKYYI SKGAIVDQLG
   121  GDLNSTPLHW ATRQGHLSMV VQLMKYGADP SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG
   181  QDVDMMDQNG MTPLMWAAYR THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV
   241  ISLLLEAGAN VDAQNIKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE
   301  FRQKVMLGTP FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF DHSMHSALPL
   361  GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY NFGKSWKSDP GIIKATEEQK
   421  KKTIVELAET GSLDLSIFCS TCLIRKPVRS KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR
   481  YFMGYLFFLL FMICWMIYGC ISYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF
   541  HFMWVAVLLM CQMYQISCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF
   601  RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • retina: 29 nTPM
  • cerebellum: 29 nTPM
  • cerebral cortex: 28 nTPM
  • bone marrow: 22 nTPM
  • endometrium: 20 nTPM
  • spinal cord: 20 nTPM

Single-cell type

  • neutrophils: 301 nCPM
  • ependymal cells: 273 nCPM
  • pdcs: 268 nCPM
  • neutrophil progenitors: 251 nCPM
  • myonuclei: 161 nCPM
  • sertoli cells: 160 nCPM

Immune cell

  • plasmacytoid DC: 17 nTPM
  • basophil: 6.2 nTPM
  • neutrophil: 5.9 nTPM
  • eosinophil: 5.8 nTPM
  • naive B-cell: 4 nTPM
  • gdT-cell: 3.6 nTPM

Brain region

  • white matter: 54 nTPM
  • cerebellum: 45 nTPM
  • cerebral cortex: 41 nTPM
  • basal ganglia: 40 nTPM
  • medulla oblongata: 38 nTPM
  • thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.57
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC17 as an antibody target. Whether an autoantibody or antibody against ZDHHC17 could matter depends on whether native ZDHHC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC17 is annotated at the cell surface, where native ZDHHC17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZDHHC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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