Seroatlas · Human Serome Atlas

EVL

Ena/VASP-like protein

Also known as: EVL_HUMAN, RNB6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UI08
Gene: EVL
Ensembl: ENSG00000196405
Chromosome: 14
Canonical length: 416 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q9UI08|EVL
     1  MSEQSICQAR ASVMVYDDTS KKWVPIKPGQ QGFSRINIYH NTASNTFRVV GVKLQDQQVV
    61  INYSIVKGLK YNQATPTFHQ WRDARQVYGL NFASKEEATT FSNAMLFALN IMNSQEGGPS
   121  SQRQVQNGPS PDEMDIQRRQ VMEQHQQQRQ ESLERRTSAT GPILPPGHPS SAASAPVSCS
   181  GPPPPPPPPV PPPPTGATPP PPPPLPAGGA QGSSHDESSM SGLAAAIAGA KLRRVQRPED
   241  ASGGSSPSGT SKSDANRASS GGGGGGLMEE MNKLLAKRRK AASQSDKPAE KKEDESQMED
   301  PSTSPSPGTR AASQPPNSSE AGRKPWERSN SVEKPVSSIL SRTPSVAKSP EAKSPLQSQP
   361  HSRMKPAGSV NDMALDAFDL DRMKQEILEE VVRELHKVKE EIIDAIRQEL SGISTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 223 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 223 nTPM
retina: 190 nTPM
basal ganglia: 179 nTPM
cerebellum: 175 nTPM
amygdala: 168 nTPM
thymus: 167 nTPM

Single-cell type

rod photoreceptor cells: 828 nCPM
cone photoreceptor cells: 476 nCPM
t-cells: 473 nCPM
nk-cells: 433 nCPM
microglia: 334 nCPM
thyrotrophs: 299 nCPM

Immune cell

T-reg: 42 nTPM
eosinophil: 28 nTPM
naive CD4 T-cell: 26 nTPM
naive CD8 T-cell: 25 nTPM
memory CD4 T-cell: 23 nTPM
gdT-cell: 20 nTPM

Brain region

cerebral cortex: 226 nTPM
basal ganglia: 191 nTPM
white matter: 169 nTPM
hypothalamus: 161 nTPM
amygdala: 161 nTPM
midbrain: 155 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.48
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EVL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVL as an antibody target. Whether an autoantibody or antibody against EVL could matter depends on whether native EVL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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