Seroatlas · Human Serome Atlas

SNAP25

Synaptosomal-associated protein 25

Also known as: bA416N4.2, dJ1068F16.2, RIC-4, RIC4, SEC9, SNAP, SNAP-25, SNP25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60880
Gene
SNAP25
Ensembl
ENSG00000132639
Chromosome
20
Canonical length
206 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>P60880|SNAP25
     1  MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI
    61  EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV
   121  VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR
   181  IMEKADSNKT RIDEANQRAT KMLGSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAP25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
2,270 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 2,270 nTPM
  • cerebral cortex: 1,847 nTPM
  • hippocampal formation: 896 nTPM
  • amygdala: 845 nTPM
  • basal ganglia: 570 nTPM
  • retina: 443 nTPM

Single-cell type

  • brain excitatory neurons: 1,192 nCPM
  • retinal bipolar cells: 837 nCPM
  • lactotrophs: 743 nCPM
  • brain inhibitory neurons: 676 nCPM
  • gonadotrophs: 584 nCPM
  • somatotrophs: 580 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 3,924 nTPM
  • white matter: 1,928 nTPM
  • cerebellum: 1,629 nTPM
  • pons: 1,334 nTPM
  • hippocampal formation: 1,153 nTPM
  • basal ganglia: 901 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNAP25.

Disease | AllUniProt

Conditions SNAP25 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 117 (DEE117) MIM:616330

Disease | GeneticClinVar

26 pathogenic / likely-pathogenic of 257 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
2.96
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAP25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAP25 as an antibody target. Whether an autoantibody or antibody against SNAP25 could matter depends on whether native SNAP25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAP25 is annotated at the cell surface, where native SNAP25 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNAP25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNAP25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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